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0CHSS3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCSS3
DescriptionChondroitin sulfate synthase 3 (ec 2.4.1.175) (glucuronosyl-n- acetylgalactosaminyl-proteoglycan 4-beta-n- acetylgalactosaminyltransferase ii) (chondroitin synthase 2) (n- acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase ii) (ec 2.4.1.226) (chondroitin glucuronyltransferase ii) (n- acetylgalactosaminyltransferase ii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family represents Chondroitin N-acetylgalactosaminyltransferase. Proteins have a type II transmembrane topology.The enzyme is involved in the biosynthetic initiation and elongation of chondroitin sulphate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulphate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulphate or heparin/heparan sulphate chains.
  IPR008428:Chondroitin N-acetylgalactosaminyltransferase
The iron-only hydrogenases () catalyse the two-electron reduction of two protons to yield dihydrogen.s part of an energy cycle. Fe-only hydrogenases are restricted to strictly anaerobic microbes.nd are often very sensitive to molecular oxygen. The cytoplasmic monomeric Fe hydrogenases are involved in hydrogen production.hile the periplasmic.eterodimeric Fe hydrogenases are involved in hydrogen uptake. Fe hydrogenases consist of two.ntertwined domains.he catalytic domain and the larger subunit C domain . The larger subunit C domain can be divided into three subdomains. There are five distinct metal clusters.ne in the catalytic domain. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009016:Iron hydrogenase
IPR008428:CHGN 
Evalue:-233.455932617187 
Location:328-864
SequencesProtein: CHSS3_HUMAN (882 aa)
mRNA: NM_175856
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00747
  Level 3 annotation:
    N-Acetylgalactosaminyltransferase II
  Level 2 annotation:
    Chondroitin sulfate biosynthesis
K03419
  Level 3 annotation:
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
  Level 2 annotation:
    Chondroitin sulfate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 268 residues, 129268421-129269223Exon2: 96 residues, 129271668-129271952Exon3: 803 residues, 129547820-129550225Exon4: 2 residues, -Jump to CHSS3_HUMAN