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0CHMP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVPS24
DescriptionCharged multivesicular body protein 3 (chromatin modifying protein 3) (vacuolar protein sorting 24) (hvps24) (neuroendocrine differentiation factor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of eukaryotic proteins which are variously described as either hypothetical protein.evelopmental protein or related to yeast SNF7. The family contains human CHMP1. CHMP1 (CHromatin Modifying Protein; CHarged Multivesicular body Protein).s encoded by an alternative open reading frame in the PRSM1 gene and is conserved in both complex and simple eukaryotes. CHMP1 contains a predicted bipartite nuclear localisation signal and distributes as distinct forms to the cytoplasm and the nuclear matrix in all cell lines tested. Human CHMP1 is strongly implicated in multivesicular body formation. A multivesicular body is a vesicle-filled endosome that targets proteins to the interior of lysosomes. Immunocytochemistry and biochemical fractionation localise CHMP1 to early endosomes and CHMP1 physically interacts with SKD1/VPS4. highly conserved protein directly linked to multivesicular body sorting in yeast. Similar to the action of a mutant SKD1 protein.ver expression of a fusion derivative of human CHMP1 dilates endosomal compartments and disrupts the normal distribution of several endosomal markers. Genetic studies in Saccharomyces cerevisiae further support a conserved role of CHMP1 in vesicle trafficking. Deletion of CHM1.he budding yeast homolog of CHMP1.esults in defective sorting of carboxypeptidases S and Y and produces abnormal.ulti-lamellar prevacuolar compartments. This phenotype classifies CHM1 as a member of the class E vacuolar protein sorting genes .
  IPR005024:Snf7
IPR005024:ESCRT-III 
Evalue:-56.6197891235352 
Location:17-187
SequencesProtein: CHMP3_HUMAN (221 aa)
mRNA: NM_016079
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 840 residues, 86584064-86586583Exon2: 40 residues, 86588112-86588227Exon3: 42 residues, 86590991-86591113Exon4: 62 residues, 86609851-86610031Exon5: 22 residues, 86622885-86622946Exon6: 60 residues, 86643937-86644111Exon7: 2 residues, -Jump to CHMP3_HUMAN  
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