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0CHM1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePCOLN3
DescriptionCharged multivesicular body protein 1a (chromatin modifying protein 1a) (chmp1a) (vacuolar protein sorting 46-1) (vps46-1) (hvps46-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000794 condensed nuclear chromosome (IDA)
0005769 early endosome (IDA)
0012505 endomembrane system (IDA)
0005815 microtubule organizing center (IDA)
0016363 nuclear matrix (IDA)
0005515 protein binding (IPI)
0016458 gene silencing (IDA)
0007076 mitotic chromosome condensation (IDA)
0045749 negative regulation of S phase of mitotic c... (IMP)
0045014 negative regulation of transcription by glu... (IDA)
0045892 negative regulation of transcription, DNA-d... (IDA)
0016192 vesicle-mediated transport (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of eukaryotic proteins which are variously described as either hypothetical protein.evelopmental protein or related to yeast SNF7. The family contains human CHMP1. CHMP1 (CHromatin Modifying Protein; CHarged Multivesicular body Protein).s encoded by an alternative open reading frame in the PRSM1 gene and is conserved in both complex and simple eukaryotes. CHMP1 contains a predicted bipartite nuclear localisation signal and distributes as distinct forms to the cytoplasm and the nuclear matrix in all cell lines tested. Human CHMP1 is strongly implicated in multivesicular body formation. A multivesicular body is a vesicle-filled endosome that targets proteins to the interior of lysosomes. Immunocytochemistry and biochemical fractionation localise CHMP1 to early endosomes and CHMP1 physically interacts with SKD1/VPS4. highly conserved protein directly linked to multivesicular body sorting in yeast. Similar to the action of a mutant SKD1 protein.ver expression of a fusion derivative of human CHMP1 dilates endosomal compartments and disrupts the normal distribution of several endosomal markers. Genetic studies in Saccharomyces cerevisiae further support a conserved role of CHMP1 in vesicle trafficking. Deletion of CHM1.he budding yeast homolog of CHMP1.esults in defective sorting of carboxypeptidases S and Y and produces abnormal.ulti-lamellar prevacuolar compartments. This phenotype classifies CHM1 as a member of the class E vacuolar protein sorting genes .
  IPR005024:Snf7
IPR005024:ESCRT-III 
Evalue:-13.2839965820313 
Location:3-173
SequencesProtein: CHM1A_HUMAN (196 aa)
mRNA: BC007527
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 551 residues, 88238345-88239996Exon2: 64 residues, 88240435-88240623Exon3: 45 residues, 88241111-88241240Exon4: 51 residues, 88243259-88243406Exon5: 28 residues, 88245477-88245555Exon6: 8 residues, 88247812-88247832Exon7: 16 residues, 88251490-88251532Exon8: 2 residues, -Jump to CHM1A_HUMAN  
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Loci Cluster (Details)Loci: 4242 88238345-88251532 ~-13K 14727(PCOLN3)(-)Loci: 4243 88331459-88410566 ~-79K 14740(FANCA)(-)Loci: 2961 88512526-88514885 ~-2K 14748(MC1R)(+)Loci: 2962 88572761-88590532 ~-18K 14760(AFG3L1)(+)Loci: 2963 88616508-88638880 ~-22K 14764(GAS8)(+)Loci: 2960 88102305-88151674 ~-49K 14720(SPG7)(+)Link out to UCSC