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0CHD6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHD6
DescriptionChromodomain-helicase-dna-binding protein 6 (chd-6) (radiation-induced gene b protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0003682 chromatin binding (NAS)
0006338 chromatin remodeling (NAS)
0007399 neurogenesis (NAS)
0006355 regulation of transcription, DNA-dependent (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in proteins involved in a variety of processes including transcription regulation (e.g..NF2.TH1.rahma.OT1).NA repair (e.g..RCC6.AD16.AD5).NA recombination (e.g..AD54).nd chromatin unwinding (e.g..SWI) as well as a variety of other proteins with little functional information (e.g..odestar.TL1) . SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex.hich utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions.esulting in the increased accessibility of DNA to transcription factors.Proteins that contain this domain appear to be distantly related to theDEAX box helicases .oweverno helicase activity has ever been demonstrated for these proteins.
  IPR000330:SNF2-related
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
The CHROMO (CHRromatin Organization MOdifier) domain .s a conserved region of around 60 amino acids.riginally identified in Drosophila modifiers of variegation.These are proteins that alter the structure of chromatin to the condensed morphology of heterochromatin. cytologically visible condition where gene expression is repressed. In one of these proteins.olycomb.he chromo domain has been shown to be important for chromatin targeting. Proteins that contain a chromo domain appear to fall into 3 classes. The first class includes proteins having an N-terminal chromo domain followed by a region termed the chromo shadow domain .g. Drosophila and human heterochromatin protein Su(var)205 (HP1). The second class includes proteins with a single chromo domain.g. Drosophila protein Polycomb (Pc); mammalian modifier 3; human Mi-2 autoantigenand and several yeast and Caenorhabditis elegans hypothetical proteins. In the third class paired tandem chromo domains are found.g. in mammalian DNA-binding/helicase proteins CHD-1 to CHD-4 and yeast protein CHD1.
  IPR000953:Chromo
BRK is a domain of unknown function found only in the metazoa and in association with CHROMO domain () and DEAD/DEAH box helicase domain ().
  IPR006576:BRK
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
IPR000330:SNF2_N 
Evalue:-99.5528411865234 
Location:464-751IPR001650:Helicase_C 
Evalue:-24.236572265625 
Location:818-897IPR000953:Chromo 
Evalue:-13.7447271347046 
Location:375-429IPR000953:Chromo 
Evalue:-9.02227592468262 
Location:292-354IPR006576:TCH 
Evalue:-6.38721609115601 
Location:2402-2442IPR000953:CHROMO_1 
Evalue:0 
Location:0-0IPR001005:SANT 
Evalue:0.176091259055681 
Location:1446-1505
SequencesProtein: CHD6_HUMAN (2715 aa)
mRNA: AY034072 NM_032221
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 987 residues, 39464583-39467543Exon2: 42 residues, 39474197-39474317Exon3: 66 residues, 39475377-39475569Exon4: 153 residues, 39477239-39477692Exon5: 71 residues, 39478641-39478848Exon6: 52 residues, 39479251-39479403Exon7: 526 residues, 39482561-39484133Exon8: 71 residues, 39485545-39485754Exon9: 74 residues, 39487231-39487448Exon10: 22 residues, 39488146-39488207Exon11: 22 residues, 39499327-39499388Exon12: 45 residues, 39502053-39502183Exon13: 36 residues, 39507718-39507822Exon14: 32 residues, 39509935-39510025Exon15: 55 residues, 39512999-39513159Exon16: 68 residues, 39513879-39514079Exon17: 69 residues, 39514793-39514996Exon18: 39 residues, 39516679-39516790Exon19: 62 residues, 39517853-39518033Exon20: 57 residues, 39519317-39519482Exon21: 67 residues, 39535375-39535571Exon22: 72 residues, 39545362-39545573Exon23: 87 residues, 39546405-39546661Exon24: 50 residues, 39549718-39549862Exon25: 61 residues, 39550481-39550658Exon26: 83 residues, 39551831-39552075Exon27: 42 residues, 39553751-39553873Exon28: 47 residues, 39555591-39555726Exon29: 31 residues, 39555911-39555998Exon30: 41 residues, 39559437-39559555Exon31: 21 residues, 39560221-39560280Exon32: 23 residues, 39561348-39561411Exon33: 52 residues, 39574898-39575048Exon34: 51 residues, 39576857-39577005Exon35: 175 residues, 39595102-39595623Exon36: 20 residues, 39613357-39613413Exon37: 53 residues, 39680392-39680547Exon38: 2 residues, -Jump to CHD6_HUMANExon1: 300 residues, 39466646-39467543Exon2: 42 residues, 39474197-39474317Exon3: 66 residues, 39475377-39475569Exon4: 153 residues, 39477239-39477692Exon5: 71 residues, 39478641-39478848Exon6: 52 residues, 39479251-39479403Exon7: 526 residues, 39482561-39484133Exon8: 71 residues, 39485545-39485754Exon9: 74 residues, 39487231-39487448Exon10: 22 residues, 39488146-39488207Exon11: 22 residues, 39499327-39499388Exon12: 45 residues, 39502053-39502183Exon13: 36 residues, 39507718-39507822Exon14: 32 residues, 39509935-39510025Exon15: 55 residues, 39512999-39513159Exon16: 68 residues, 39513879-39514079Exon17: 69 residues, 39514793-39514996Exon18: 39 residues, 39516679-39516790Exon19: 62 residues, 39517853-39518033Exon20: 57 residues, 39519317-39519482Exon21: 67 residues, 39535375-39535571Exon22: 72 residues, 39545362-39545573Exon23: 87 residues, 39546405-39546661Exon24: 50 residues, 39549718-39549862Exon25: 61 residues, 39550481-39550658Exon26: 83 residues, 39551831-39552075Exon27: 42 residues, 39553751-39553873Exon28: 47 residues, 39555591-39555726Exon29: 31 residues, 39555911-39555998Exon30: 41 residues, 39559437-39559555Exon31: 21 residues, 39560221-39560280Exon32: 23 residues, 39561348-39561411Exon33: 52 residues, 39574898-39575048Exon34: 51 residues, 39576857-39577005Exon35: 175 residues, 39595102-39595623Exon36: 20 residues, 39613357-39613413Exon37: 53 residues, 39680392-39680547Exon38: 2 residues, -Jump to CHD6_HUMAN  
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Loci Cluster (Details)Loci: 4522 39464583-39680547 ~-216K 23108(CHD6)(-)Loci: 3256 39199574-39237771 ~-38K 23100(PLCG1)(+)Link out to UCSC