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0CETN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCETN1
DescriptionCentrin-1 (caltractin isoform 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005813 centrosome (TAS)
0005856 cytoskeleton (TAS)
0005816 spindle pole body (TAS)
0005509 calcium ion binding (TAS)
0007067 mitosis (TAS)
0007100 mitotic centrosome separation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR002048:efhand 
Evalue:-8.61978912353516 
Location:32-60IPR002048:efhand 
Evalue:-8.09151458740234 
Location:141-169IPR002048:efhand 
Evalue:-5.76955127716064 
Location:68-96IPR002048:efhand 
Evalue:-3.17392516136169 
Location:105-133
SequencesProtein: CETN1_HUMAN (172 aa)
mRNA: NM_004066
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 386 residues, 570368-571524Exon2: 2 residues, -Jump to CETN1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3052 895316-899680 ~-4K 16989(ADCYAP1)(+)Loci: 3051 570368-571524 ~-1K 16976(CETN1)(+)Link out to UCSC