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0CEP57_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTSP57
DescriptionCentrosomal protein of 57 kda (cep57 protein) (testis-specific protein 57) (translokin) (fgf2-interacting protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005813 centrosome (IDA)
0005874 microtubule (IDA)
0017134 fibroblast growth factor binding (IPI)
0042803 protein homodimerization activity (IPI)
0008543 fibroblast growth factor receptor signaling... (IPI)
0000060 protein-nucleus import, translocation (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several uncharacterised mammalian proteins of unknown function.
  IPR010597:Protein of unknown function DUF1167
The 20S proteasome is a multicatalytic complex that is responsible for the non-lysosomal degradation of intracellular proteins. The proteasome is composed of a catalytic core that is regulated by protein complexes.hich bind to the ends of the cylindrical core structure. One of these regulatory complexes is the PA28 activator complex (also known as the 11S regulator.r REG). ring-shaped hexameric structure that enhances the peptidase activity of the core enzyme. Three REG subunits have been isolated.EGalpha.EGbeta and REGgamma. REGalpha and REGbeta preferentially form a heteromeric complex with alternating alpha and beta subunits. The structure of the human REGalpha subunit reveals a heptameric barrel-shaped assembly containing a central channel . The binding of REG is thought to create a pore through with substrates and products can pass.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009077:Proteasome activator, REGalpha subunit
IPR010597:DUF1167 
Evalue:-1e+125 
Location:31-500
SequencesProtein: CEP57_HUMAN (500 aa)
mRNA: NM_014679
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 89 residues, 95163289-95163555Exon2: 54 residues, 95172043-95172200Exon3: 62 residues, 95185743-95185923Exon4: 42 residues, 95186279-95186401Exon5: 41 residues, 95190598-95190715Exon6: 28 residues, 95191638-95191716Exon7: 38 residues, 95194682-95194790Exon8: 28 residues, 95195310-95195388Exon9: 82 residues, 95200597-95200839Exon10: 50 residues, 95201998-95202143Exon11: 557 residues, 95203837-95205502Exon12: 2 residues, -Jump to CEP57_HUMAN  
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