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0CDS2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDS2
DescriptionPhosphatidate cytidylyltransferase 2 (ec 2.7.7.41) (cdp-diglyceride synthetase 2) (cdp-diglyceride pyrophosphorylase 2) (cdp- diacylglycerol synthase 2) (cds 2) (ctp:phosphatidate cytidylyltransferase 2) (cdp-dag synthase 2) (cdp-dg synthetase 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0005743 mitochondrial inner membrane (NAS)
0004605 phosphatidate cytidylyltransferase activity (NAS)
0008654 phospholipid biosynthesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phosphatidate cytidylyltransferase () (also known as CDP-diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis ofCDP-diacylglycerol from CTP and phosphatidate (PA):CTP + phosphatidate = diphosphate + CDP-diacylglycerolCDP-diacylglycerol is animportant branch point intermediate in both prokaryotic and eukaryoticorganisms. CDS is a membrane-bound enzyme.
  IPR000374:Phosphatidate cytidylyltransferase
IPR000374:CTP_transf_1 
Evalue:-139.05061340332 
Location:70-400
SequencesProtein: CDS2_HUMAN (445 aa)
mRNA: NM_003818
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00981
  Level 3 annotation:
    phosphatidate cytidylyltransferase
  Level 2 annotation:
    Glycerophospholipid metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 105 residues, 5055481-5055795Exon2: 47 residues, 5102168-5102305Exon3: 34 residues, 5103828-5103925Exon4: 34 residues, 5105293-5105391Exon5: 48 residues, 5107462-5107602Exon6: 21 residues, 5111032-5111091Exon7: 29 residues, 5111706-5111789Exon8: 31 residues, 5113503-5113591Exon9: 25 residues, 5114403-5114472Exon10: 53 residues, 5115332-5115485Exon11: 42 residues, 5117712-5117832Exon12: 36 residues, 5118380-5118484Exon13: 415 residues, 5118747-5119987Exon14: 2 residues, -Jump to CDS2_HUMAN  
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Loci Cluster (Details)Loci: 4507 5230622-5243059 ~-12K 22662(GPR73L1)(-)Loci: 3235 5055481-5119987 ~-65K 22661(CDS2)(+)Link out to UCSC