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0CDC42_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDC42
DescriptionCell division control protein 42 homolog (g25k gtp-binding protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IDA)
0030175 filopodium (NAS)
0005886 plasma membrane (IDA)
0003924 GTPase activity (NAS)
0005515 protein binding (ISS)
0007015 actin filament organization (NAS)
0007163 establishment and/or maintenance of cell po... (TAS)
0030225 macrophage differentiation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rho subfamily of Ras-like small GTPases include Cdc42 and Rac.s well as Rho isoforms.The crystal structure of a number of the members of this entry have been determined: Rnd3/RhoE .hoA and Cdc42 .
  IPR003578:Ras small GTPase, Rho type
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003578:RHO 
Evalue:-130.886056647693 
Location:6-179
SequencesProtein: CDC42_HUMAN (191 aa)
mRNA: NM_044472
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK04393
  Level 3 annotation:
    cell division cycle 42
  Level 2 annotation:
    MAPK signaling pathway
    GTP-binding proteins
    Regulation of actin cytoskeleton
    Focal adhesion
    Adherens junction
    Tight junction
    T cell receptor signaling pathway
    Leukocyte transendothelial migration
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 19 residues, 22251768-22251822Exon2: 53 residues, 22277508-22277663Exon3: 26 residues, 22280801-22280874Exon4: 38 residues, 22285518-22285628Exon5: 68 residues, 22285748-22285946Exon6: 185 residues, 22289022-22289571Exon7: 2 residues, -Jump to CDC42_HUMAN  
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Loci Cluster (Details)Loci: 2488 22251768-22289571 ~-38K 631(CDC42)(+)Loci: 3778 22021324-22136334 ~-115K 626(HSPG2)(-)Link out to UCSC