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0CD81_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCD81
DescriptionCd81 antigen (26 kda cell surface protein tapa-1) (target of the antiproliferative antibody 1) (tetraspanin-28) (tspan-28).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (IDA)
0005515 protein binding (IPI)
0000187 activation of MAPK activity (IDA)
0006661 phosphatidylinositol biosynthesis (IDA)
0030384 phosphoinositide metabolism (IDA)
0043128 positive regulation of 1-phosphatidylinosit... (IDA)
0030890 positive regulation of B cell proliferation (ISS)
0008284 positive regulation of cell proliferation (IDA)
0050731 positive regulation of peptidyl-tyrosine ph... (IDA)
0008104 protein localization (IDA)
0046718 viral entry into host cell (TAS)
0046813 virion attachment, binding of host cell sur... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of eukaryotic CD antigens have been shown to be related. CD9 (also called DRAP-27.RP-1 or p24) upregulates HB-EGF activity as a receptor for diphtheria toxin as well as its juxtacrine activity. CD9 mAbs modulate cell adhesion and migration and trigger platelet activation that is blocked by mAbs directed to the platelet Fc receptor CD32. In mice.D9 mAb KMC8.8 has been shown to inhibit the production of myeloid cells in vitro and has a costimulatory activity for T cells. CD9 is a type III membrane protein.ith four putative transmembrane domains. CD37 (or gp52-40) is involved in signal transduction and serves as a stable marker for malignancies derived from mature B cells.ike B-CLL.CL.nd all types of B-NHL. CD63 transfection reduced melanoma cell motility on fibronectin.ollagen and laminin.nd reduced the growth and metastasis of melanoma cells in nude mice . CD63 has been used as a marker for late endosomes and for primary melanomas.These proteins are all type II membrane proteins: they contain anN-terminal transmembrane (TM) domain.hich acts both as a signal sequenceand a membrane anchor.nd 3 additional TM regions (hence the name TM4).The sequences contain a number of conserved cysteine residues.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR000301:CD9/CD37/CD63 antigen
Tetraspanins are a distinct family of proteins.ontaining four transmembrane domains: a small outer loop (EC1). larger outer loop (EC2). small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features.ncluding 4-6 conserved extracellular cysteine residues.nd polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains.ometimes called the tetraspanin web. Within this web there are primary complexes in which tetraspanins show robust.pecific.nd direct lateral associations with other proteins. The strong tendency of tetraspanins to associate with each other probably contributes to the assembly of a network of secondary interactions in which non-tetraspanin proteins are associated with each other via palmitoylated tetraspanins acting as linker proteins. In addition.he association of lipids.uch as gangliosides and cholesterol.robably contributes to the assembly of even larger tetraspanin complexes.hich have some lipid raft-like properties (e.g. resistance to solubilization in non-ionic detergents). Within the tetraspanin web.etraspanin proteins can associate not only with integrins and other transmembrane proteins.ut also with signalling enzymes such as protein kinase C and phosphatidylinositol-4 kinase. Thus.he tetraspanin web provides a mechanistic framework by which membrane protein signalling can be expanded into a lateral dimension . The tetraspanin domain consists of 5 helices in an irregular disulphide-linked array which plays a role in form homodimerization.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008952:Tetraspanin
IPR000301:Tetraspannin 
Evalue:-67 
Location:9-216
SequencesProtein: CD81_HUMAN (236 aa)
mRNA: NM_004356
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK06508
  Level 3 annotation:
    CD81 antigen
  Level 2 annotation:
    CD molecules
    B cell receptor signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 100 residues, 2355122-2355421Exon2: 40 residues, 2368217-2368332Exon3: 34 residues, 2371900-2371998Exon4: 27 residues, 2372777-2372852Exon5: 37 residues, 2373221-2373326Exon6: 36 residues, 2373674-2373776Exon7: 31 residues, 2374433-2374520Exon8: 207 residues, 2374609-2375225Exon9: 2 residues, -Jump to CD81_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3930 2141735-2149605 ~-8K 6153(TH)(-)Loci: 2645 2355122-2375225 ~-20K 6164(CD81)(+)Loci: 2646 2422796-2826915 ~-404K 6167(KCNQ1)(+)Loci: 2644 1812281-1815326 ~-3K 6136(SYT8)(+)Link out to UCSC