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0CD5R2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDK5R2
DescriptionCyclin-dependent kinase 5 activator 2 precursor (cdk5 activator 2) (cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39i).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000079 regulation of cyclin dependent protein kina... (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
These proteins are activators of cyclin-dependent kinase 5. They are heterodimers of a catalytic subunit and a regulatory subunit.
  IPR004944:Cyclin-dependent kinase 5 activator
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011028:Cyclin-like
IPR004944:CDK5_activator 
Evalue:-229.443695068359 
Location:1-332
SequencesProtein: CD5R2_HUMAN (367 aa)
mRNA: NM_003936
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 827 residues, 219532641-219535120Exon2: 2 residues, -Jump to CD5R2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3213 219232701-219236409 ~-4K 22084(BCS1L)(+)Loci: 3214 219354948-219388259 ~-33K 22089(CYP27A1)(+)Loci: 3215 219532641-219535120 ~-2K 22095(CDK5R2)(+)Loci: 4494 219782737-219791916 ~-9K 22116(ABCB6)(-)Loci: 3216 219991342-219999703 ~-8K 22140(DES)(+)Loci: 3217 220087295-220111732 ~-24K 22148(ACCN4)(+)Loci: 3218 220145197-220148671 ~-3K 22154(INHA)(+)Loci: 4493 219210885-219232599 ~-22K 22082(ZNF142)(-)Link out to UCSC