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0CD59_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCD59
DescriptionCd59 glycoprotein precursor (membrane attack complex inhibition factor) (macif) (mac-inhibitory protein) (mac-ip) (protectin) (mem43 antigen) (membrane inhibitor of reactive lysis) (mirl) (20 kda homologous restriction factor) (hrf-20) (hrf20) (1f5 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005624 membrane fraction (TAS)
0005886 plasma membrane (NAS)
0005515 protein binding (IPI)
0007596 blood coagulation (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
CD59 (also called 1F-5Ag.19.RF20.ACIF.IRL.-18 or protectin) inhibits formation of membrane attack complex (MAC).hus protecting cells from complement mediated lysis. It has a signaling role.s a GPI-anchored molecule.n T cell activation and appears to have some role in cell adhesion through CD2 (controversial). CD59 associates with C9.nhibiting incorporation into C5b-8 preventing terminal steps in polymerization of the (MAC) in plasma membranes. Genetic defects in GPI-anchor attachment that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal nocturnal hemoglobinuria (PNH). A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved domain of about 100 amino-acid residues . Among these proteins.-PAR contains three tandem copies of the domain.hile all the others are made up of a single domain.As shown in the following schematic.his conserved domain contains 10 cysteine residues involved in five disulphide bonds - in U-PAR.he first copy of the domain lacks the fourth disulphide bond.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001526:CD59 antigen
A number of GPI-linked cell-surface glycoproteins are related. These include prostate stem cell antigen.ymphocyte antigen LY-6H and CD59 glycoprotein.lso known as MAC-inhibitory protein.
  IPR003632:Cell-surface glycoprotein Ly-6/CD59
IPR001526:UPAR_LY6 
Evalue:-32.4559326171875 
Location:28-95
SequencesProtein: CD59_HUMAN (128 aa)
mRNA: NM_203330
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 2445 residues, 33681133-33688465Exon2: 36 residues, 33695491-33695593Exon3: 30 residues, 33700500-33700585Exon4: 17 residues, 33709545-33709590Exon5: 40 residues, 33711616-33711732Exon6: 34 residues, 33714503-33714600Exon7: 2 residues, -Jump to CD59_HUMAN  
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