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0CD47_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCD47
DescriptionLeukocyte surface antigen cd47 precursor (integrin-associated protein) (iap) (antigenic surface determinant protein oa3) (mer6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0007229 integrin-mediated signaling pathway (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family represents the CD47 leukocyte antigen V-set like Ig domain .
  IPR013270:CD47 immunoglobulin-like
This family represents the transmembrane region of CD47 leukocyte antigen .
  IPR013147:CD47 transmembrane
CD47 (integrin-associated protein.AP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. For example.D47-induces caspase-independent cell death which may be mediated by cytoskeleton reorganization . In red blood cells.D47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha . The protein can also act as a thrombospondin receptor . This pattern also recognises a group of CD-47-like proteins found in Capripoxvirus.
  IPR006704:CD47 integrin associated protein
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR013270:V-set_CD47 
Evalue:-80.3665313720703 
Location:8-142IPR013147:CD47 
Evalue:-74.9208221435547 
Location:143-300
SequencesProtein: CD47_HUMAN (323 aa)
mRNA: NM_001025080 NM_001777
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK06266
  Level 3 annotation:
    CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
  Level 2 annotation:
    ECM-receptor interaction
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1400 residues, 109244630-109248829Exon2: 13 residues, 109251155-109251188Exon3: 10 residues, 109252114-109252139Exon4: 12 residues, 109253475-109253507Exon5: 33 residues, 109259013-109259106Exon6: 33 residues, 109259873-109259966Exon7: 33 residues, 109260988-109261081Exon8: 38 residues, 109262281-109262389Exon9: 32 residues, 109272629-109272719Exon10: 120 residues, 109281527-109281881Exon11: 77 residues, 109292399-109292625Exon12: 2 residues, -Jump to CD47_HUMANExon1: 1400 residues, 109244630-109248829Exon2: 13 residues, 109251155-109251188Exon3: 10 residues, 109252114-109252139Exon4: 12 residues, 109253475-109253507Exon5: 17 residues, 109257056-109257103Exon6: 33 residues, 109259013-109259106Exon7: 33 residues, 109259873-109259966Exon8: 33 residues, 109260988-109261081Exon9: 38 residues, 109262281-109262389Exon10: 32 residues, 109272629-109272719Exon11: 120 residues, 109281527-109281881Exon12: 77 residues, 109292399-109292625Exon13: 2 residues, -Jump to CD47_HUMAN  
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