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0CD3G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionT-cell surface glycoprotein cd3 gamma chain precursor (t-cell receptor t3 gamma chain).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (NAS)
0042101 T cell receptor complex (NAS)
0046982 protein heterodimerization activity (IPI)
0030159 receptor signaling complex scaffold activity (NAS)
0042608 T cell receptor binding (NAS)
0004888 transmembrane receptor activity (IMP)
0007166 cell surface receptor linked signal transdu... (IMP)
0007163 establishment and/or maintenance of cell po... (IMP)
0006461 protein complex assembly (NAS)
0015031 protein transport (IMP)
0042981 regulation of apoptosis (IMP)
0042110 T cell activation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . This entry represents a subtype of the immunoglobulin domain.nd is found in a diverse range of protein families that includes glycoproteins.ibroblast growth factor receptors.ascular endothelial growth factor receptors.nterleukin-6 receptor.nd neural cell adhesion molecules. It also includes proteins that are classified as unassigned proteinase inhibitors belonging to MEROPS inhibitor families I2.17 and I43 .
  IPR003598:Immunoglobulin subtype 2
Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases . Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.
  IPR003110:Phosphorylated immunoreceptor signaling ITAM
SequencesProtein: CD3G_HUMAN (182 aa)
mRNA: NM_000073
Local Annotation
Synapse Ontology
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 32 residues, 117720310-117720403Exon2: 10 residues, 117724951-117724975Exon3: 78 residues, 117725667-117725895Exon4: 46 residues, 117726476-117726608Exon5: 16 residues, 117727552-117727596Exon6: 30 residues, 117728328-117728412Exon7: 74 residues, 117729043-117729261Exon8: 2 residues, -Jump to CD3G_HUMAN  
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Loci Cluster (Details)Loci: 3997 117509303-117528745 ~-19K 7842(SCN4B)(-)Loci: 3998 117538729-117552546 ~-14K 7844(SCN2B)(-)Loci: 2710 117720310-117729261 ~-9K 7856(CD3G)(+)Loci: 2711 117812414-117901144 ~-89K 7860(MLL)(+)Loci: 2712 117948320-117978854 ~-31K 7867(ARCN1)(+)Loci: 2713 118394450-118399592 ~-5K 7892(TRAPPC4)(+)Loci: 3999 118794097-118799064 ~-5K 7924(THY1)(-)Loci: 2709 117452975-117494380 ~-41K 7838(TMPRSS4)(+)Link out to UCSC