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0CCR5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCCR5
DescriptionC-c chemokine receptor type 5 (c-c ckr-5) (cc-ckr-5) (ccr-5) (ccr5) (hiv-1 fusion coreceptor) (chemr13) (cd195 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0016493 C-C chemokine receptor activity (NAS)
0015026 coreceptor activity (TAS)
0004435 phosphoinositide phospholipase C activity (TAS)
0007267 cell-cell signaling (TAS)
0006968 cellular defense response (TAS)
0006935 chemotaxis (TAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0006954 inflammatory response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatoryprocesses. Their sequences are similar and are characterised by a4-cysteine motif: the family can be divided according to whether thefirst 2 Cys residues are adjacent (the C-C family).r separated by anintervening residue (the C-x-C family). C-C chemokines are chemoattractantfor monocytes but not for neutrophils. The C-C family includes humanmonocyte chemotactic protein-1 (MCP-1).egulated on activation.ormalT cell expressed and secreted (RANTES) and macrophage inflammatory proteins(MIP-1a and MIP-1b) .C-C chemokine receptors are found in monocytes.ymphocytes.asophils andeosinophils; mRNA is also found in some cell lines. MCP-1 and MIP-1ainduce activation in low nanomolar concentrations and are highly selectiverelative to C-x-C receptors. Calcium mobilisation has been demonstrated inmonocytes and in cells expressing the recombinant C-C receptor via anuncharacterised G-protein; pertussis toxin inhibits some of its actions .
  IPR000355:Chemokine receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatoryprocesses. Their sequences are similar and are characterised by a4-cysteine motif: the family can be divided according to whether thefirst 2 Cys residues are adjacent (the C-C family).r separated by anintervening residue (the C-x-C family). C-C chemokines are chemoattractantfor monocytes but not for neutrophils. The C-C family includes humanmonocyte chemotactic protein-1 (MCP-1).egulated on activation.ormalT cell expressed and secreted (RANTES) and macrophage inflammatory proteins(MIP-1a and MIP-1b) .C-C chemokine receptors are found in monocytes.ymphocytes.asophils andeosinophils; mRNA is also found in some cell lines. MCP-1 and MIP-1ainduce activation in low nanomolar concentrations and are highly selectiverelative to C-x-C receptors. Calcium mobilisation has been demonstrated inmonocytes and in cells expressing the recombinant C-C receptor via anuncharacterised G-protein; pertussis toxin inhibits some of its actions .A novel chemokine receptor.ncoded 18 kilobase pairs downstream of the MCP-1 receptor (CCR2) gene on human chromosome 3p21.as been identified . The deduced amino acid sequence of the receptor.esignated CCR5.s most similar to CCR2B.haring 71% identical residues . Transfected cells expressing the receptor bind RANTES.IP-1beta and MIP-1alpha with high affinity.nd generate inositol phosphates in response to these chemokines. The same combination of chemokines has been shown potently to inhibit human immunodeficiency virus replication in human peripheral blood leukocytes .CCR5 is expressed in lymphoid organs.uch as thymus and spleen.s well as in peripheral blood leukocytes.ncluding macrophages and T cells .
  IPR002240:C-C chemokine receptor, type 5
IPR000276:7tm_1 
Evalue:-81.4814834594727 
Location:47-297IPR000355:CCCHEMOKINER 
Evalue:0 
Location:20-38IPR002240:CHEMOKINER5 
Evalue:0 
Location:322-336IPR000355:CCCHEMOKINER 
Evalue:0 
Location:299-313
SequencesProtein: CCR5_HUMAN (352 aa)
mRNA: NM_000579
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK04180
  Level 3 annotation:
    chemokine (C-C motif) receptor 5
  Level 2 annotation:
    G-protein coupled receptors
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 20 residues, 46386636-46386693Exon2: 98 residues, 46387194-46387483Exon3: 1104 residues, 46389386-46392694Exon4: 2 residues, -Jump to CCR5_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 20 residues, 664914-664971Exon2: 98 residues, 665472-665761Exon3: 1104 residues, 667659-670967Exon4: 2 residues, -Jump to CCR5_HUMAN