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0CCR4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCCR4
DescriptionC-c chemokine receptor type 4 (c-c ckr-4) (cc-ckr-4) (ccr-4) (ccr4) (k5-5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004950 chemokine receptor activity (TAS)
0006935 chemotaxis (TAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)
0006954 inflammatory response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Angiotensin II is the principal mediator of the renin-angiotensin system;it circulates in the bloodstream.timulating vasoconstriction andretention of salt and water . It also stimulates increased fluid intakeand regulates the neuroendocrine system. Many of its actions are mediatedby release of hormones from endocrine glands..g. vasopressin.atecholamines.ldosterone.rowth-hormone.tc. Molecular cloning studies haveidentified 2 major receptor subtypes.esignated AT1 and AT2.AT1 receptors are the major subclass of the angiotensin family. Thereceptors are found in blood vessels.ther smooth muscles (e.g..heuterus and bladder).nd endocrine glands. Receptors are also presentin the kidney.iver and on presynaptic nerve terminals.here theypotentiate release of noradrenaline. They are distributed widely inthe CNS and are present in high levels in the hypothalamus and anteriorpituitary.here they stimulate release of vasopressin and ACTH res.AT1 receptors inhibit adenylyl cyclase and activate phosphoinositidemetabolism via a pertussis-toxin-insensitive G-protein.robably of theGq/G11 class .
  IPR000190:AT1 angiotensin II receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatoryprocesses. Their sequences are similar and are characterised by a4-cysteine motif: the family can be divided according to whether thefirst 2 Cys residues are adjacent (the C-C family).r separated by anintervening residue (the C-x-C family). C-C chemokines are chemoattractantfor monocytes but not for neutrophils. The C-C family includes humanmonocyte chemotactic protein-1 (MCP-1).egulated on activation.ormalT cell expressed and secreted (RANTES) and macrophage inflammatory proteins(MIP-1a and MIP-1b) .C-C chemokine receptors are found in monocytes.ymphocytes.asophils andeosinophils; mRNA is also found in some cell lines. MCP-1 and MIP-1ainduce activation in low nanomolar concentrations and are highly selectiverelative to C-x-C receptors. Calcium mobilisation has been demonstrated inmonocytes and in cells expressing the recombinant C-C receptor via anuncharacterised G-protein; pertussis toxin inhibits some of its actions .
  IPR000355:Chemokine receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatoryprocesses. Their sequences are similar and are characterised by a4-cysteine motif: the family can be divided according to whether thefirst 2 Cys residues are adjacent (the C-C family).r separated by anintervening residue (the C-x-C family). C-C chemokines are chemoattractantfor monocytes but not for neutrophils. The C-C family includes humanmonocyte chemotactic protein-1 (MCP-1).egulated on activation.ormalT cell expressed and secreted (RANTES) and macrophage inflammatory proteins(MIP-1a and MIP-1b) .C-C chemokine receptors are found in monocytes.ymphocytes.asophils andeosinophils; mRNA is also found in some cell lines. MCP-1 and MIP-1ainduce activation in low nanomolar concentrations and are highly selectiverelative to C-x-C receptors. Calcium mobilisation has been demonstrated inmonocytes and in cells expressing the recombinant C-C receptor via anuncharacterised G-protein; pertussis toxin inhibits some of its actions .The murine homologue of human CC chemokine receptor-4 (CC CKR-4) has beencloned . The gene product is 85% identical to human CC CKR-4.o whichit shows similar binding characteristics and tissue distribution . MurineCC CKR-4 was detected in the thymus and T-cell lines by Northern blotanalysis .
  IPR002239:C-C chemokine receptor, type 4
IPR000276:7tm_1 
Evalue:-84.0362091064453 
Location:56-304IPR002239:CHEMOKINER4 
Evalue:0 
Location:338-358IPR000355:CCCHEMOKINER 
Evalue:0 
Location:29-47IPR002239:CHEMOKINER4 
Evalue:0 
Location:12-28IPR000355:CCCHEMOKINER 
Evalue:0 
Location:306-320
SequencesProtein: CCR4_HUMAN (360 aa)
mRNA: NM_005508
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
KO assignmentK04179
  Level 3 annotation:
    chemokine (C-C motif) receptor 4
  Level 2 annotation:
    G-protein coupled receptors
    Cytokine receptors
    Cytokine-cytokine receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 40 residues, 32968069-32968186Exon2: 515 residues, 32969867-32971407Exon3: 2 residues, -Jump to CCR4_HUMAN  
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