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0CCNE1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCCNE1
DescriptionG1/s-specific cyclin e1.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0050681 androgen receptor binding (NAS)
0005515 protein binding (IPI)
0003713 transcription coactivator activity (NAS)
0030521 androgen receptor signaling pathway (NAS)
0000082 G1/S transition of mitotic cell cycle (NAS)
0045893 positive regulation of transcription, DNA-d... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .Cyclins contain two domains of similar all-alpha fold.f which this entry is associated with the N-terminal domain.
  IPR006671:Cyclin, N-terminal
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.
  IPR013763:Cyclin-related
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .This domain is also found in transcription factor IIB (TFIIB) and retinoblastoma.
  IPR006670:Cyclin
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .This is the C-terminal domain of cyclins.
  IPR004367:Cyclin, C-terminal
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles .nd regulate cyclin dependent kinases (CDKs). Cyclins.ogether with the p34 (cdc2) or cdk2 kinases.orm the Maturation Promoting Factor (MPF). There are two main groups of cyclins.1/S cyclins.hich are essential for the control of the cell cycle at the G1/S (start) transition.nd G2/M cyclins.hich are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species.here are multiple forms of G1 and G2 cyclins. For example.n vertebrates.here are two G2 cyclins. and B.nd at least three G1 cyclins...nd E.Cyclin homologues have been found in various viruses.ncluding herpesvirus saimiri and Kaposis sarcoma-associated herpesvirus. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus .This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011028:Cyclin-like
IPR006671:Cyclin_N 
Evalue:-58.3467864990234 
Location:115-242IPR004367:Cyclin_C 
Evalue:-21.7212467193604 
Location:244-370
SequencesProtein: CCNE1_HUMAN (410 aa)
mRNA: NM_001238
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK06626
  Level 3 annotation:
    cyclin E
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 34994740-34994899Exon2: 17 residues, 34995278-34995325Exon3: 31 residues, 34995435-34995523Exon4: 25 residues, 34995715-34995784Exon5: 50 residues, 34999883-35000029Exon6: 47 residues, 35000152-35000288Exon7: 51 residues, 35003448-35003595Exon8: 34 residues, 35004468-35004564Exon9: 47 residues, 35004742-35004877Exon10: 39 residues, 35004986-35005098Exon11: 54 residues, 35005192-35005350Exon12: 221 residues, 35006401-35007058Exon13: 2 residues, -Jump to CCNE1_HUMAN  
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