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0CCL22_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCCL22
DescriptionSmall inducible cytokine a22 precursor (ccl22) (macrophage-derived chemokine) (mdc(1-69)) (stimulated t cell chemotactic protein 1) (cc chemokine stcp-1) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (TAS)
0008009 chemokine activity (TAS)
0019735 antimicrobial humoral response (sensu Verte... (TAS)
0007267 cell-cell signaling (TAS)
0006935 chemotaxis (TAS)
0006954 inflammatory response (TAS)
0009615 response to virus (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Synonym(s): cytokine.ntecrineMany low-molecular weight factors secreted by cells including fibroblasts.acrophages and endothelial cells.n response to a variety of stimuli such as growth factors.nterferons.iral transformation and bacterial products.re structurally related . Most members of this family of proteins seem to have mitogenic.hemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds.s shown in the following schematic representation:These proteins can be sorted into two groups based on the spacing of the two amino-terminal cysteines. In the first group (see ).he two cysteines are separated by a single residue (C-x-C).hile in the second group (see ).hey are adjacent (C-C).
  IPR001811:Small chemokine, interleukin-8-like
Most members of this family of low-molecular weight proteins seem to havemitogenic.hemotactic or inflammatory activities. They are released by phagocytes.esenchymal cells and a wide variety of tissue cells.pon exposure to inflammation. These small cytokines are also called intercrines or chemokines. Theyare cationic proteins of 70 to 100 amino acid residues that share four conservedcysteine residues involved in two disulphide bonds.The family can be split into two groups.epending on the spacing of two N-terminalCys residues: in one group (CxC).he cysteines are separated by asingle amino acid; in the second (CC).hey are adjacent . The CxCgroup includes such factors as interleukin-8.latelet factor 4.elanoma growthstimulatory activity protein.acrophage inflammatory protein 2.latelet basicprotein.nd several others. The C-C group includes the monocyte chemotacticproteins.acrophage inflammatory proteins and others.The accumulation of neutrophil leukocytes in tissues is a major event in inflammation. defensive reaction in response to injury or infection . Neutrophils are drawn in from the blood by chemotactic signals that direct their migration to the affected site. Interleukin-8 (IL8) is one such chemotactic protein: it is released by phagocytes.esenchymal cells and a wide variety of tissue cells.pon exposure to inflammation; and it acts as a neutrophil-activating cytokine.nducing chemotaxis.xo- cytosis.nd the respiratory burst.
  IPR002473:Small chemokine, C-X-C/Interleukin 8
IPR001811:SCY 
Evalue:-22.1135092748275 
Location:33-91IPR002473:INTERLEUKIN8 
Evalue:0 
Location:1-24
SequencesProtein: CCL22_HUMAN (93 aa)
mRNA: NM_002990
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 29 residues, 55950218-55950302Exon2: 43 residues, 55951849-55951973Exon3: 896 residues, 55954916-55957600Exon4: 2 residues, -Jump to CCL22_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2944 56327160-56348663 ~-22K 14187(KATNB1)(+)Loci: 4226 56349631-56393909 ~-44K 14188(KIFC3)(-)Loci: 4227 56749316-56789283 ~-40K 14207(CSNK2A2)(-)Loci: 4228 57112105-57221249 ~-109K 14223(-)Loci: 2943 55950218-55957600 ~-7K 14167(CCL22)(+)Link out to UCSC