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0CCG7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCACNG7
DescriptionVoltage-dependent calcium channel gamma-7 subunit (neuronal voltage- gated calcium channel gamma-7 subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005891 voltage-gated calcium channel complex (NAS)
0005245 voltage-gated calcium channel activity (NAS)
0006816 calcium ion transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .
  IPR008368:Voltage-dependent calcium channel gamma
InterPro domains unassigned to SynO:
Several vertebrate small integral membrane glycoproteins are evolutionary related .ncluding eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1).hich is also known as tumor-associatedmembrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2).hich is also known as XMP; epithelial membrane protein-3 (EMP-3).lso known as YMP;and peripheral myelin protein 22 (PMP-22).hich is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size.nd contain four transmembrane segments. PMP-22.MP-1.2 and -3 are highly similar.hile MP20 is more distantly related. This family also includes the claudins.hich are components of tight junctions.
  IPR004031:PMP-22/EMP/MP20 and claudin
Transient receptor potential (Trp) and related proteins are thought to be Ca2+ ion channel subunits that mediate capacitative Ca2+ entry in response to a range of external and internal cell stimuli. Such Ca2+ entry is thought to be an essential component of cellular responses to many hormones and growth factors.nd acts to replenish intracellular Ca2+ stores that have been emptied through the action of inositol triphosphate (IP3) and other agents. In non-excitable cells..e. those that lack voltage-gated Ca2+ channels.uch as hepatocytes.his mode of Ca2+ entry is thought to be an important step in generating the oscillations of intracellular Ca2+ concentration that characterise their response to stimulatory agents . Studies on the visual transduction system in Drosophila led to the molecular cloning of Trp and the cDNA of a related protein.rp-like.hich show similarity to voltage gated Ca2+ channels in the regions known as S3 through S6.ncluding the S5-S6 linker that forms the ion-selective channel pore . This provided evidence that Trp and/or related proteins might form mammalian capacitative Ca2+ entry channels. A number of Trp and Trp-like channel gene isoforms have now been cloned.ncluding several mammalian homologues. The Trp family is thought to encode at least 20 Ca2+-permeable channel proteins. Hydropathy analysis suggests that they share a common transmembrane (TM) topology. Each family member is predicted to possess 6 TM domains with intracellular N- and C-termini.hich is similar to the core structure of the pore-forming subunits of the voltage-gated Na+ and Ca2+ channels. By analogy with these proteins.hich have 4 linked domains of 6 TM segments.t is likely that Trp channels are homo- or heterotetramers of 4 single subunits . The Trp family can be divided on the basis of sequence similarity into 3 subfamilies: short (S).ong (L) and osm-like (O) Trp channels. The STrp subfamily includes Drosophila Trp and Trpl-like.nd the mammalian homologues TrpC1-7. Channels of the STrpC subfamily are activated following receptor-mediated stimulation of different isoforms of phospholipase C .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .The VDCCG-7 subunit was identified by high throughput genomic sequencedatabase searching.ursuing sequences similar to VDCCG-1 to -5.Mouse and human isofroms have been cloned. VDCCG-7 is expressed in a rangeof tissues including brain.idney.iver.mall intestine and testis .
  IPR008371:Voltage-dependent calcium channel, gamma-7 subunit
IPR004031:PMP22_Claudin 
Evalue:-7.85387182235718 
Location:7-196IPR008371:VDCCGAMMA7 
Evalue:0 
Location:259-271
SequencesProtein: CCG7_HUMAN (275 aa)
mRNA: NM_031896
Local Annotation
Synapse Ontology
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
c-fos proto-oncogenes
sdb:0214 c-fos proto-oncogene  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
CREB-binding protein.
sdb:0217 CBP  (Evidence:domains)
KO assignmentK04872
  Level 3 annotation:
    calcium channel, voltage-dependent, gamma subunit 7
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 71 residues, 59107882-59108093Exon2: 31 residues, 59109565-59109652Exon3: 49 residues, 59110430-59110571Exon4: 50 residues, 59136535-59136681Exon5: 328 residues, 59137101-59138080Exon6: 2 residues, -Jump to CCG7_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3136 59107882-59138080 ~-30K 19560(CACNG7)(+)Loci: 3137 59158105-59177951 ~-20K 19561(CACNG8)(+)Loci: 3138 59187353-59207730 ~-20K 19562(CACNG6)(+)Loci: 4416 59432280-59438429 ~-6K 19590(-)Loci: 3135 59077278-59102713 ~-25K 19559(PRKCG)(+)Link out to UCSC