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0CCG6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCACNG6
DescriptionVoltage-dependent calcium channel gamma-6 subunit (neuronal voltage- gated calcium channel gamma-6 subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005891 voltage-gated calcium channel complex (NAS)
0005245 voltage-gated calcium channel activity (NAS)
0006816 calcium ion transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .
  IPR008368:Voltage-dependent calcium channel gamma
InterPro domains unassigned to SynO:
Zona occludens (ZO).r tight junctions (TJ).re specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells that create a primary barrier.reventing paracellular transport of solutes.nd restricting the lateral diffusion of membrane lipids and proteins.hus maintaining cellular polarity . Under freeze-fracture electron microscopy.Js appear as a network of continuous anastomosing intramembranous strands. These strands consist mainly of claudins and occludin ().hich are transmembrane proteins that polymerise within plasma membranes to form fibrils . The claudin protein family is encoded by at least 17 human genes.ith many homologues cloned from other species. Tissue distribution patterns for the claudin family members are distinct. Claudin-1 and -2.or example.re expressed at high levels in the liver and kidney.hereas claudin-3 mRNA is detected mainly in the lung and liver . This suggests that multiple claudin family members may be involved in tight junction strand formation in a tissue-dependent manner. Hydropathy analysis suggests that all claudins share a common transmembrane (TM) topology. Each family member is predicted to possess four TM domains with intracellular N and C termini. Although their C-terminal cytoplasmic domain sequences vary.ost claudin family members share a common motif of -Y-V in this region. This has been postulated as a possible binding motif for PDZ domains of other tight junction-associated membrane proteins.uch as ZO-1 ().
  IPR006187:Claudin tight junction protein
Transient receptor potential (Trp) and related proteins are thought to be Ca2+ ion channel subunits that mediate capacitative Ca2+ entry in response to a range of external and internal cell stimuli. Such Ca2+ entry is thought to be an essential component of cellular responses to many hormones and growth factors.nd acts to replenish intracellular Ca2+ stores that have been emptied through the action of inositol triphosphate (IP3) and other agents. In non-excitable cells..e. those that lack voltage-gated Ca2+ channels.uch as hepatocytes.his mode of Ca2+ entry is thought to be an important step in generating the oscillations of intracellular Ca2+ concentration that characterise their response to stimulatory agents . Studies on the visual transduction system in Drosophila led to the molecular cloning of Trp and the cDNA of a related protein.rp-like.hich show similarity to voltage gated Ca2+ channels in the regions known as S3 through S6.ncluding the S5-S6 linker that forms the ion-selective channel pore . This provided evidence that Trp and/or related proteins might form mammalian capacitative Ca2+ entry channels. A number of Trp and Trp-like channel gene isoforms have now been cloned.ncluding several mammalian homologues. The Trp family is thought to encode at least 20 Ca2+-permeable channel proteins. Hydropathy analysis suggests that they share a common transmembrane (TM) topology. Each family member is predicted to possess 6 TM domains with intracellular N- and C-termini.hich is similar to the core structure of the pore-forming subunits of the voltage-gated Na+ and Ca2+ channels. By analogy with these proteins.hich have 4 linked domains of 6 TM segments.t is likely that Trp channels are homo- or heterotetramers of 4 single subunits . The Trp family can be divided on the basis of sequence similarity into 3 subfamilies: short (S).ong (L) and osm-like (O) Trp channels. The STrp subfamily includes Drosophila Trp and Trpl-like.nd the mammalian homologues TrpC1-7. Channels of the STrpC subfamily are activated following receptor-mediated stimulation of different isoforms of phospholipase C .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins.The VDCCG-6 subunit was identified by high throughput genomic sequencedatabase searching.ursuing sequences similar to VDCCG-1 to -5 .Mouse.uman and rat isoforms have been cloned. VDCCG-6 is expressed in arange of tissues including brain.idney.ung.keletal muscle.rostateand testis .
  IPR008370:Voltage-dependent calcium channel, gamma-6 subunit
IPR006187:CLAUDIN 
Evalue:0 
Location:214-238IPR006187:CLAUDIN 
Evalue:0 
Location:136-158IPR006187:CLAUDIN 
Evalue:0 
Location:168-189IPR008368:VDCCGAMMA 
Evalue:0 
Location:46-64IPR008370:VDCCGAMMA6 
Evalue:0 
Location:14-32IPR008370:VDCCGAMMA6 
Evalue:0 
Location:91-109IPR008370:VDCCGAMMA6 
Evalue:0 
Location:2-13IPR008370:VDCCGAMMA6 
Evalue:0 
Location:65-76
SequencesProtein: CCG6_HUMAN (260 aa)
mRNA: NM_145814
Local Annotation
Synapse Ontology
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
c-fos proto-oncogenes
sdb:0214 c-fos proto-oncogene  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
CREB-binding protein.
sdb:0217 CBP  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 308 residues, 59187353-59188274Exon2: 27 residues, 59193304-59193379Exon3: 48 residues, 59194699-59194837Exon4: 240 residues, 59207016-59207730Exon5: 2 residues, -Jump to CCG6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3136 59107882-59138080 ~-30K 19560(CACNG7)(+)Loci: 3137 59158105-59177951 ~-20K 19561(CACNG8)(+)Loci: 3138 59187353-59207730 ~-20K 19562(CACNG6)(+)Loci: 4416 59432280-59438429 ~-6K 19590(-)Loci: 3135 59077278-59102713 ~-25K 19559(PRKCG)(+)Link out to UCSC