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0CCG4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCACNG4
DescriptionVoltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005245 voltage-gated calcium channel activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .
  IPR008368:Voltage-dependent calcium channel gamma
InterPro domains unassigned to SynO:
Several vertebrate small integral membrane glycoproteins are evolutionary related .ncluding eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1).hich is also known as tumor-associatedmembrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2).hich is also known as XMP; epithelial membrane protein-3 (EMP-3).lso known as YMP;and peripheral myelin protein 22 (PMP-22).hich is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size.nd contain four transmembrane segments. PMP-22.MP-1.2 and -3 are highly similar.hile MP20 is more distantly related. This family also includes the claudins.hich are components of tight junctions.
  IPR004031:PMP-22/EMP/MP20 and claudin
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels . The voltage-dependent calcium channel gamma (VDCCG) subunit family consists of at least 8 members.hich share a number of common structural features . Each member is predicted to possess four TM domains.ith intracellular N- and C- termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues. The C-terminal seven residues of VDCCG-2.3.4 and -8 are also conserved and contain a consensus site for phosphorylation by cAMP and cGMP-dependent protein kinases.nd a target site for binding by PDZ domain proteins. The VDCCG-4 subunit is predominantly expressed in neuronal tissue.lthough there is some evidence for expression in lung and prostate . The modulatory properties of the subunit have been investigated using heterologous expression systems. Coexpression of the VDCGG-4 subunit with P/Q-type channels shifts the steady-state inactivation curve of these channels to more hyperpolarised potentials .
  IPR005423:Voltage-dependent calcium channel gamma-4 subunit
Zona occludens (ZO).r tight junctions (TJ).re specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells that create a primary barrier.reventing paracellular transport of solutes.nd restricting the lateral diffusion of membrane lipids and proteins.hus maintaining cellular polarity . Under freeze-fracture electron microscopy.Js appear as a network of continuous anastomosing intramembranous strands. These strands consist mainly of claudins and occludin ().hich are transmembrane proteins that polymerise within plasma membranes to form fibrils . The claudin protein family is encoded by at least 17 human genes.ith many homologues cloned from other species. Tissue distribution patterns for the claudin family members are distinct. Claudin-1 and -2.or example.re expressed at high levels in the liver and kidney.hereas claudin-3 mRNA is detected mainly in the lung and liver . This suggests that multiple claudin family members may be involved in tight junction strand formation in a tissue-dependent manner. Hydropathy analysis suggests that all claudins share a common transmembrane (TM) topology. Each family member is predicted to possess four TM domains with intracellular N and C termini. Although their C-terminal cytoplasmic domain sequences vary.ost claudin family members share a common motif of -Y-V in this region. This has been postulated as a possible binding motif for PDZ domains of other tight junction-associated membrane proteins.uch as ZO-1 ().
  IPR006187:Claudin tight junction protein
IPR004031:PMP22_Claudin 
Evalue:-48.2518119812012 
Location:6-202IPR005423:VDCCGAMMA4 
Evalue:0 
Location:287-299IPR005423:VDCCGAMMA4 
Evalue:0 
Location:223-234IPR005423:VDCCGAMMA4 
Evalue:0 
Location:264-274
SequencesProtein: CCG4_HUMAN (327 aa)
mRNA: NM_014405
Local Annotation
Synapse Ontology
a kind of potentiation that decays over a course of more than 20 min. long-lasting forms of LTP and LTD have been identified that require new gene expression and protein synthesis.
sdb:0192 long-term plasticity  (Evidence:keywords,domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:keywords,domains)
c-fos proto-oncogenes
sdb:0214 c-fos proto-oncogene  (Evidence:keywords,domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords,domains)
CREB-binding protein.
sdb:0217 CBP  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentK04869
  Level 3 annotation:
    calcium channel, voltage-dependent, gamma subunit 4
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 79 residues, 62391474-62391709Exon2: 30 residues, 62444766-62444850Exon3: 49 residues, 62451437-62451578Exon4: 981 residues, 62457043-62459980Exon5: 2 residues, -Jump to CCG4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3030 62391474-62459980 ~-69K 16466(CACNG4)(+)Loci: 3031 62471167-62483371 ~-12K 16467(CACNG1)(+)Loci: 3029 62303852-62311857 ~-8K 16465(CACNG5)(+)Link out to UCSC