SynDB Home Page
SynDB Home Page

blue bulletSynDB protein details  

Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0CCG3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionVoltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005891 voltage-gated calcium channel complex (NAS)
0005245 voltage-gated calcium channel activity (NAS)
0006816 calcium ion transport (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/ [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .
  IPR008368:Voltage-dependent calcium channel gamma
InterPro domains unassigned to SynO:
Several vertebrate small integral membrane glycoproteins are evolutionary related .ncluding eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1).hich is also known as tumor-associatedmembrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2).hich is also known as XMP; epithelial membrane protein-3 (EMP-3).lso known as YMP;and peripheral myelin protein 22 (PMP-22).hich is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size.nd contain four transmembrane segments. PMP-22.MP-1.2 and -3 are highly similar.hile MP20 is more distantly related. This family also includes the claudins.hich are components of tight junctions.
  IPR004031:PMP-22/EMP/MP20 and claudin
Zona occludens (ZO).r tight junctions (TJ).re specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells that create a primary barrier.reventing paracellular transport of solutes.nd restricting the lateral diffusion of membrane lipids and proteins.hus maintaining cellular polarity . Under freeze-fracture electron microscopy.Js appear as a network of continuous anastomosing intramembranous strands. These strands consist mainly of claudins and occludin ().hich are transmembrane proteins that polymerise within plasma membranes to form fibrils . The claudin protein family is encoded by at least 17 human genes.ith many homologues cloned from other species. Tissue distribution patterns for the claudin family members are distinct. Claudin-1 and -2.or expressed at high levels in the liver and kidney.hereas claudin-3 mRNA is detected mainly in the lung and liver . This suggests that multiple claudin family members may be involved in tight junction strand formation in a tissue-dependent manner. Hydropathy analysis suggests that all claudins share a common transmembrane (TM) topology. Each family member is predicted to possess four TM domains with intracellular N and C termini. Although their C-terminal cytoplasmic domain sequences vary.ost claudin family members share a common motif of -Y-V in this region. This has been postulated as a possible binding motif for PDZ domains of other tight junction-associated membrane proteins.uch as ZO-1 ().
  IPR006187:Claudin tight junction protein
SequencesProtein: CCG3_HUMAN (315 aa)
mRNA: NM_006539
Local Annotation
Synapse Ontology
a kind of potentiation that decays over a course of more than 20 min. long-lasting forms of LTP and LTD have been identified that require new gene expression and protein synthesis.
sdb:0192 long-term plasticity  (Evidence:keywords,domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:keywords,domains)
c-fos proto-oncogenes
sdb:0214 c-fos proto-oncogene  (Evidence:keywords,domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords,domains)
CREB-binding protein.
sdb:0217 CBP  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentK04868
  Level 3 annotation:
    calcium channel, voltage-dependent, gamma subunit 3
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 471 residues, 24174376-24175787Exon2: 30 residues, 24265555-24265639Exon3: 49 residues, 24273654-24273795Exon4: 356 residues, 24280173-24281237Exon5: 2 residues, -Jump to CCG3_HUMAN  
Tune and view alternative isoforms