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0CCG1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCACNG1
DescriptionVoltage-dependent calcium channel gamma-1 subunit (dihydropyridine- sensitive l-type, skeletal muscle calcium channel gamma subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005891 voltage-gated calcium channel complex (TAS)
0015270 dihydropyridine-sensitive calcium channel a... (TAS)
0006936 muscle contraction (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels .The voltage-dependent calcium channel gamma (VDCCG) subunit family consistsof at least 8 members.hich share a number of common structural features. Each member is predicted to possess 4 transmembrane domains.ith intracellularN- and C-termini. The first extracellular loop contains a highly conservedN-glycosylation site and a pair of conserved cysteine residues. TheC-terminal 7 residues of VDCCG-2.3.4 and -8 are also conserved andcontain a consensus site for phosphorylation by cAMP and cGMP-dependentprotein kinases.nd a target site for binding by PDZ domain proteins .
  IPR008368:Voltage-dependent calcium channel gamma
InterPro domains unassigned to SynO:
Several vertebrate small integral membrane glycoproteins are evolutionary related .ncluding eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1).hich is also known as tumor-associatedmembrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2).hich is also known as XMP; epithelial membrane protein-3 (EMP-3).lso known as YMP;and peripheral myelin protein 22 (PMP-22).hich is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size.nd contain four transmembrane segments. PMP-22.MP-1.2 and -3 are highly similar.hile MP20 is more distantly related. This family also includes the claudins.hich are components of tight junctions.
  IPR004031:PMP-22/EMP/MP20 and claudin
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels . The voltage-dependent calcium channel gamma (VDCCG) subunit family consists of at least 8 members.hich share a number of common structural features . Each member is predicted to possess four TM domains.ith intracellular N- and C- termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues. The C-terminal seven residues of VDCCG-2.3.4 and -8 are also conserved and contain a consensus site for phosphorylation by cAMP and cGMP-dependent protein kinases.nd a target site for binding by PDZ domain proteins.The VDCCG-1 subunit is a 25kDa protein expressed exclusively in skeletal muscle cells.here it functions as a dihydropyridine-sensitive.-type calcium channel subunit . The modulatory properties of VDCCG-1 subunits have been investigated using heterologous expression systems. Coexpression of VDCCG-1 subunits with L-type or P/Q-type channels induces moderate changes in activation and inactivation properties.nd modification of the peak current amplitude of these channels .
  IPR005421:Voltage-dependent calcium channel gamma-1 subunit
IPR004031:PMP22_Claudin 
Evalue:-4.92081880569458 
Location:5-199
SequencesProtein: CCG1_HUMAN (222 aa)
mRNA: NM_000727
Local Annotation
Synapse Ontology
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
c-fos proto-oncogenes
sdb:0214 c-fos proto-oncogene  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
CREB-binding protein.
sdb:0217 CBP  (Evidence:domains)
KO assignmentK04866
  Level 3 annotation:
    calcium channel, voltage-dependent, gamma subunit 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 101 residues, 62471167-62471467Exon2: 27 residues, 62480573-62480648Exon3: 48 residues, 62481680-62481818Exon4: 251 residues, 62482622-62483371Exon5: 2 residues, -Jump to CCG1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3030 62391474-62459980 ~-69K 16466(CACNG4)(+)Loci: 3031 62471167-62483371 ~-12K 16467(CACNG1)(+)Loci: 3029 62303852-62311857 ~-8K 16465(CACNG5)(+)Link out to UCSC