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0CBP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCREBBP
DescriptionCreb-binding protein (ec 2.3.1.48).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005634 nucleus (TAS)
0005515 protein binding (IPI)
0004871 signal transducer activity (TAS)
0003713 transcription coactivator activity (IPI)
0003700 transcription factor activity (TAS)
0042592 homeostasis (NAS)
0006461 protein complex assembly (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)
0001666 response to hypoxia (TAS)
0007165 signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain of unknown function is found in several eukaryotic transcriptional co-activators.
  IPR009255:Transcriptional coactivation
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner . This provides a model for activator:coactivator interactions. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.
  IPR003101:Coactivator CBP, KIX
CBP and the related protein p300 are large nuclear molecules that interactwith transcriptional activators and repressors. They belong to a class ofprotein containing a histone acetyltransferase activity.hich suggest a rolein chromatin remodeling. They are involved in biological function as diverse as cell growth.ifferentiation.r apoptosis .CBP/P300 proteins contain in their N and C terminal parts the so calledtranscriptional adaptor putative zinc finger (TAZ finger).Each TAZ domain is an around 100 amino acids domain which shows an internaltriplication of a Cys-x4-Cys-x8-His-x3-Cys motif.lthough some of the repeatsare imperfect. The binding sites for YY1.1A and TFIIB in CBP and P300proteins have been mapped in the region that contain the TAZ finger.uggesting a possible protein-binding function for this motif.Proteins containing this domain have been found to bind phosphorylated CREB.
  IPR000197:Zinc finger, TAZ-type
Bromodomains are found in a variety of mammalian.nvertebrate and yeast DNA-binding proteins . Bromodomains can interact withacetylated lysine .In some proteins.he classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g..ammalian protein HRX.aenorhabditis elegans hypothetical protein ZK783.4.east protein YTA7). The bromodomain may occur as a single copy.r in duplicate. The precise function of the domain is unclear.ut it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation .
  IPR001487:Bromodomain
This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein which is an acetyltransferase that acetylates histones.iving a specific tag for transcriptional activation. CREB-binding protein also acetylates non-histone proteins.
  IPR010303:Protein of unknown function DUF902, CREBbp
Skeletal muscle dystrophin is a 427 kDa protein thought to act as a link between the actin cytoskeleton and the extracellular matrix. Perturbations of the dystrophin-associated complex.or example.etween dystrophin and the transmembrane glycoprotein beta-dystroglycan.ay lead to muscular dystrophy. Previously.he cysteine-rich region and first half of the carboxy-terminal domain of dystrophin were shown to interact with beta-dystroglycan through a stretch of fifteen amino acids at the carboxy-terminus of beta-dystroglycan. This region of dystrophin implicated in binding beta-dystroglycan contains four modular protein domains: a WW domain.wo putative Ca2+-binding EF-hand motifs.nd a putative zinc finger ZZ domain .
  IPR000433:Zinc finger, ZZ-type
IPR009255:DUF906 
Evalue:-190.494842529297 
Location:1316-1553IPR003101:KIX 
Evalue:-51.6197891235352 
Location:587-667IPR000197:zf-TAZ 
Evalue:-48.2924308776856 
Location:348-432IPR001487:BROMO 
Evalue:-42.3872161432803 
Location:1084-1194IPR000197:zf-TAZ 
Evalue:-38.7212448120117 
Location:1764-1843IPR000433:ZZ 
Evalue:-19.32790184021 
Location:1701-1742IPR003439:ABC_TRANSPORTER_1 
Evalue:0 
Location:123-137
SequencesProtein: CBP_HUMAN (2442 aa)
mRNA: U85962
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK04498
  Level 3 annotation:
    E1A/CREB binding protein
  Level 2 annotation:
    Wnt signaling pathway
    Notch signaling pathway
    TGF-beta signaling pathway
    Jak-STAT signaling pathway
    Cell cycle
    Adherens junction
    Long-term potentiation
    Huntington's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 720 residues, 3717719-3719876Exon2: 96 residues, 3721193-3721475Exon3: 56 residues, 3721777-3721939Exon4: 58 residues, 3726037-3726205Exon5: 57 residues, 3726651-3726817Exon6: 40 residues, 3728560-3728674Exon7: 51 residues, 3729579-3729726Exon8: 52 residues, 3730400-3730551Exon9: 24 residues, 3734895-3734963Exon10: 28 residues, 3735278-3735356Exon11: 21 residues, 3739628-3739685Exon12: 29 residues, 3741727-3741808Exon13: 31 residues, 3747289-3747378Exon14: 82 residues, 3747810-3748050Exon15: 41 residues, 3748855-3748974Exon16: 65 residues, 3757721-3757911Exon17: 62 residues, 3759175-3759355Exon18: 141 residues, 3760571-3760988Exon19: 62 residues, 3763752-3763932Exon20: 43 residues, 3764570-3764695Exon21: 17 residues, 3767614-3767659Exon22: 59 residues, 3768012-3768184Exon23: 41 residues, 3768701-3768819Exon24: 51 residues, 3770733-3770880Exon25: 36 residues, 3771205-3771308Exon26: 83 residues, 3772685-3772928Exon27: 40 residues, 3781982-3782096Exon28: 82 residues, 3783387-3783628Exon29: 61 residues, 3800604-3800781Exon30: 239 residues, 3840298-3841011Exon31: 298 residues, 3869833-3870723Exon32: 2 residues, -Jump to CBP_HUMAN  
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Loci Cluster (Details)Loci: 2919 3036682-3050723 ~-14K 13385(MMP25)(+)Loci: 4203 3232028-3246628 ~-15K 13403(MEFV)(-)Loci: 2920 3273487-3281456 ~-8K 13405(ZNF263)(+)Loci: 4204 3571183-3601586 ~-30K 13423(BTBD12)(-)Loci: 4205 3648039-3707514 ~-59K 13426(TRAP1)(-)Loci: 4206 3717719-3870723 ~-153K 13429(CREBBP)(-)Loci: 4202 2962794-2970475 ~-8K 13372(PKMYT1)(-)Link out to UCSC