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0CBLN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCBLN1
DescriptionCerebellin precursor (precerebellin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007399 neurogenesis (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
C1q is a subunit of the C1 enzyme complex that activates the serum complementsystem. C1q comprises 6 A. B and 6 C chains. These share the same topology.achpossessing a small.lobular N-terminal domain. collagen-like Gly/Pro-rich centralregion.nd a conserved C-terminal region.he C1q domain . The C1qprotein is produced in collagen-producing cells and shows sequence and structuralsimilarity to collagens VIII and X .
  IPR001073:Complement C1q protein
The tumour necrosis factor (TNF)-like domains are found in both TNF and C1q protein families. Structurally these domains self-associate to make a compact bell-shaped homotrimer.ach monomer being composed of an anti-parallel beta-sheet sandwich with a jellyroll topology. Both TNF and C1q family members can be expressed as soluble plasma proteins or as type II membrane-bound proteins. TNF family members bind extracellularly to cysteine-rich receptors.hereby inducing a clustering of the receptors.hich subsequently triggers the intracellular apoptotic cascade. The TNF proteins are important mediators in inflammation.mmune responses and cytotoxicity through their interaction with the TNF-R55 and the TNF-R75 cell-surface receptors . Other TNF family members include the CD40 ligand (C-terminal TNF-like domain) which is involved in the immune response via the CD40 receptor .RAIL which selectively induces apoptosis in tumour cells via DR4 and DR5 receptors .he RANK ligand which triggers osteoclastogenesis via the RANK receptor .nd TALL-1 (soluble domain) which is involved in the immune response via the TACI.CMA.nd BAFF-R receptors . C1q proteins also contain TNF-like domains. C1q family members include the serum protein ACRP30 (C-terminal TNF-like domain) which may be involved in energy homeostasis and obesity.nd X-NC1 (C-terminal TNF-like domain) which is crucial for collagen X assembly in bone tissue . The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008983:TNF-like
IPR001073:C1Q 
Evalue:-64.1804560644581 
Location:55-193
SequencesProtein: CBLN1_HUMAN (193 aa)
mRNA: NM_004352
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 271 residues, 47870201-47871013Exon2: 42 residues, 47872334-47872454Exon3: 192 residues, 47872613-47873184Exon4: 2 residues, -Jump to CBLN1_HUMAN  
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