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0CASR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCASR
DescriptionExtracellular calcium-sensing receptor precursor (casr) (parathyroid cell calcium-sensing receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0004435 phosphoinositide phospholipase C activity (TAS)
0006874 calcium ion homeostasis (TAS)
0005513 calcium ion sensing (TAS)
0007635 chemosensory behavior (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0009653 morphogenesis (TAS)
0001503 ossification (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.The calcium-sensing receptor (CaSR) is an integral membrane protein thatsenses changes in the extracellular concentration of calcium ions. Theactivity of the receptor is mediated by a G-protein that activates aphosphatidyl-inositol-calcium second messenger system. The sequences of thereceptors show a high degree of similarity to the TM signature thatcharacterises the metabotropic glutamate receptors. In addition.hesequences contain a large extracellular domain that includes clusters ofacidic amino acid residues.hich may be involved in calcium binding .Defects in CaSR that result in reduced activity of the receptor causefamilial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT).nherited conditions characterised by altered calciumhomeostasis . FHH-affected individuals exhibit mild or modest hypercalcemia.elative hypocalciuria and inappropriately normal PTH levels. Bycontrast.SHPT is a rare autosomal recessive life-threatening disordercharacterised by high serum calcium concentrations.keletal demineralisation and parathyroid hyperplasia. In addition.efects resulting fromreceptor activation at subnormal Ca2+ levels cause autosomal dominanthypocalcemia .
  IPR000068:Extracellular calcium-sensing receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane.ethered to in several receptor proteins.
  IPR011500:Nine cysteines of 3 GPCR
IPR000337:7tm_3 
Evalue:-140.698974609375 
Location:616-867IPR001828:ANF_receptor 
Evalue:-108.119186401367 
Location:69-496IPR011500:NCD3G 
Evalue:-19.5850257873535 
Location:538-574IPR000068:CASENSINGR 
Evalue:0 
Location:506-526IPR000068:CASENSINGR 
Evalue:0 
Location:42-58IPR000068:CASENSINGR 
Evalue:0 
Location:15-30
SequencesProtein: CASR_HUMAN (1078 aa)
mRNA: NM_000388 U20760
Local Annotation
Synapse Ontology
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04612
  Level 3 annotation:
    calcium-sensing receptor
  Level 2 annotation:
    G-protein coupled receptors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 123385219-123385349Exon2: 144 residues, 123455484-123455911Exon3: 104 residues, 123458617-123458924Exon4: 297 residues, 123463064-123463949Exon5: 79 residues, 123477348-123477579Exon6: 43 residues, 123483649-123483773Exon7: 938 residues, 123485223-123488032Exon8: 2 residues, -Jump to CASR_HUMANExon1: 66 residues, 123385870-123386066Exon2: 144 residues, 123455484-123455911Exon3: 104 residues, 123458617-123458924Exon4: 297 residues, 123463064-123463949Exon5: 79 residues, 123477348-123477579Exon6: 53 residues, 123483619-123483773Exon7: 938 residues, 123485223-123488032Exon8: 2 residues, -Jump to CASR_HUMAN  
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