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0CASL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNEDD9
DescriptionEnhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (p105) (neural precursor cell expressed developmentally down-regulated 9).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005634 nucleus (TAS)
0005819 spindle (TAS)
0005515 protein binding (IPI)
0051017 actin filament bundle formation (NAS)
0007155 cell adhesion (NAS)
0007010 cytoskeleton organization and biogenesis (NAS)
0007229 integrin-mediated signaling pathway (NAS)
0000074 regulation of progression through cell cycle (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR001452:SH3 
Evalue:-16.4089353929735 
Location:6-64
SequencesProtein: CASL_HUMAN (834 aa)
mRNA: NM_006403
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 791 residues, 11291519-11293890Exon2: 32 residues, 11296436-11296526Exon3: 416 residues, 11298182-11299424Exon4: 36 residues, 11300563-11300665Exon5: 36 residues, 11301809-11301911Exon6: 151 residues, 11321499-11321946Exon7: 56 residues, 11340722-11340884Exon8: 2 residues, -Jump to CASL_HUMAN  
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