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0CART_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCART
DescriptionCocaine- and amphetamine-regulated transcript protein precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (TAS)
0007267 cell-cell signaling (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding.nd completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypothalamus.nd can be transcriptionally induced after cocaine or amphetamine administration . Posttranslational processing of CART produces an N-terminal CART peptide and a C-terminal CART peptide. The C-terminal CART peptide has been isolated from the hypothalamus.ucleus accumbens.nd the anterior pituitary lobe in rats. C-terminal CART is the biologically active part of the molecule affecting food intake. The structure of C-terminal CART consists of a disulphide-bound fold containing a beta-hairpin and two adjacent disulphide bridges .
  IPR009106:CART satiety factor
IPR009106:CART 
Evalue:-89.2441253662109 
Location:1-116
SequencesProtein: CART_HUMAN (116 aa)
mRNA: NM_004291
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 71050749-71051035Exon2: 30 residues, 71051462-71051546Exon3: 181 residues, 71052090-71052628Exon4: 2 residues, -Jump to CART_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 1675812-1676098Exon2: 30 residues, 1676525-1676609Exon3: 181 residues, 1677153-1677691Exon4: 2 residues, -Jump to CART_HUMAN  
Loci Cluster (Details)Loci: 3464 71050749-71052628 ~-2K 28983(CART)(+)Loci: 3465 71438890-71538608 ~-100K 28984(MAP1B)(+)Loci: 4717 71551111-71651809 ~-101K 28987(MRPS27)(-)Loci: 3463 70918909-70988981 ~-70K 28982(MCCC2)(+)Link out to UCSC  
Loci: 3517 1675812-1677691 ~-2K 30188(CART)(+)Loci: 3516 1543972-1614044 ~-70K 30187(MCCC2)(+)Link out to UCSC