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0CAPON_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNOS1AP
DescriptionCarboxyl-terminal pdz ligand of neuronal nitric oxide synthase protein (c--terminal pdz ligand of neuronal nitric oxide synthase protein) (nitric oxide synthase 1 adaptor protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (ISS)
0050998 nitric-oxide synthase binding (ISS)
0030165 PDZ domain binding (ISS)
0005515 protein binding (ISS)
0007269 neurotransmitter secretion (ISS)
0050999 regulation of nitric-oxide synthase activity (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain. 7-stranded beta-sandwich.apped by a C-terminal helix.However.he PI domain contains an additional short N-terminal helix and alarge insertion between strands 1 and 2.hich forms a helix and 2 longconnecting loops. The substrate peptide fits into a surface cleft formedfrom the C-terminal helix and strand 5 .
  IPR006020:Phosphotyrosine interaction region
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling proteins.here they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C delta-1.eta-spectrin.ynamin.on-of-sevenless.rp1.nc-89.app1 and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
IPR006020:PID 
Evalue:-49.6989707946777 
Location:32-175
SequencesProtein: CAPON_HUMAN (506 aa)
mRNA: NM_014697
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 165 residues, 160306204-160306696Exon2: 26 residues, 160390818-160390890Exon3: 33 residues, 160523757-160523850Exon4: 26 residues, 160537046-160537120Exon5: 38 residues, 160569430-160569539Exon6: 49 residues, 160580248-160580390Exon7: 57 residues, 160591600-160591767Exon8: 61 residues, 160593373-160593550Exon9: 57 residues, 160601817-160601983Exon10: 464 residues, 160603465-160604852Exon11: 2 residues, -Jump to CAPON_HUMAN  
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