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0CANT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCANT1
DescriptionSoluble calcium-activated nucleotidase 1 (ec 3.6.1.6) (scan-1) (apyrase homolog) (putative nf-kappa-b-activating protein 107) (putative mapk-activating protein pm09).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004871 signal transducer activity (IMP)
0043123 positive regulation of I-kappaB kinase/NF-k... (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several eukaryotic apyrase proteins (). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate .
  IPR009283:Apyrase
IPR009283:Apyrase 
Evalue:-241.481491088867 
Location:86-401
SequencesProtein: CANT1_HUMAN (401 aa)
mRNA: AF328554 NM_138793
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01510
  Level 3 annotation:
    apyrase
  Level 2 annotation:
    Purine metabolism
    Pyrimidine metabolism
    CD molecules
K01511
  Level 3 annotation:
    nucleoside-diphosphatase
  Level 2 annotation:
    Purine metabolism
    Pyrimidine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 735 residues, 74499393-74501597Exon2: 70 residues, 74502694-74502898Exon3: 326 residues, 74504668-74505640Exon4: 33 residues, 74517340-74517433Exon5: 2 residues, -Jump to CANT1_HUMANExon1: 145 residues, 74501163-74501597Exon2: 70 residues, 74502694-74502898Exon3: 219 residues, 74504668-74505321Exon4: 43 residues, 74505516-74505640Exon5: 48 residues, 74505824-74505963Exon6: 38 residues, 74517340-74517449Exon7: 2 residues, -Jump to CANT1_HUMAN  
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