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0CALM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCALM1
DescriptionCalmodulin (cam).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005886 plasma membrane (TAS)
0005509 calcium ion binding (TAS)
0005515 protein binding (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Recoverin. retinal calcium-binding protein.elongs to the larger family ofproteins which have an EF-hand calcium-binding domain. Recoverinparticipates in the recovery phase of visual excitation and in adaption to light.The Ca2+-bound form of recoverin prolongs the photoresponse.resumably by blockingphosphorylation of photoexcited rhodopsin. Recoverin contains a covalently-attachedmyristoyl group.r acyl group.t its N-terminus.nd two Ca2+-binding sites .A number of other proteins including visinin.ippocalcin.eurocalcin.-modulin.isinin-like protein.nd frequenin belong to this family. All of thefamily memebers have the aromatic residues that contribute to the myristoyl-bindingpocket.
  IPR001125:Recoverin
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR002048:efhand 
Evalue:-9.30980396270752 
Location:84-112IPR002048:efhand 
Evalue:-9.03151702880859 
Location:120-148IPR002048:efhand 
Evalue:-8.6777811050415 
Location:11-39IPR002048:efhand 
Evalue:-8.30103015899658 
Location:47-75
SequencesProtein: CALM_HUMAN (148 aa)
mRNA: BC007965 BC011834 BC047553 NM_001743 NM_005184
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 214 residues, 47240808-47241447Exon2: 47 residues, 47242365-47242501Exon3: 37 residues, 47242928-47243035Exon4: 50 residues, 47243161-47243305Exon5: 12 residues, 47251376-47251407Exon6: 25 residues, 47257083-47257154Exon7: 2 residues, -Jump to CALM_HUMANExon1: 213 residues, 47240810-47241447Exon2: 47 residues, 47242365-47242501Exon3: 37 residues, 47242928-47243035Exon4: 50 residues, 47243161-47243305Exon5: 1160 residues, 47251376-47254850Exon6: 2 residues, -Jump to CALM_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 62 residues, 51796351-51796534Exon2: 12 residues, 51800923-51800954Exon3: 50 residues, 51803293-51803437Exon4: 37 residues, 51803578-51803685Exon5: 47 residues, 51803942-51804078Exon6: 554 residues, 51804221-51805878Exon7: 2 residues, -Jump to CALM_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 68 residues, 89933128-89933330Exon2: 12 residues, 89936161-89936192Exon3: 50 residues, 89937355-89937499Exon4: 37 residues, 89939958-89940065Exon5: 47 residues, 89940475-89940611Exon6: 308 residues, 89940785-89941704Exon7: 2 residues, -Jump to CALM_HUMANExon1: 75 residues, 89934361-89934585Exon2: 12 residues, 89936161-89936192Exon3: 50 residues, 89937355-89937499Exon4: 37 residues, 89939958-89940065Exon5: 47 residues, 89940475-89940611Exon6: 141 residues, 89940785-89941203Exon7: 2 residues, -Jump to CALM_HUMAN  
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Loci Cluster (Details)Loci: 3116 50100878-50104489 ~-4K 19057(APOE)(+)Loci: 3117 50234137-50266053 ~-32K 19065(SFRS16)(+)Loci: 4398 50407718-50429309 ~-22K 19076(-)Loci: 3118 50446389-50500381 ~-54K 19078(MARK4)(+)Loci: 4399 50546685-50565669 ~-19K 19089(ERCC2)(-)Loci: 4400 50747641-50779917 ~-32K 19109(OPA3)(-)Loci: 4401 50804499-50834509 ~-30K 19111(EML2)(-)Loci: 3119 50863341-50877557 ~-14K 19113(GIPR)(+)Loci: 4402 51134630-51168497 ~-34K 19134(NOVA2)(-)Loci: 3120 51542133-51585943 ~-44K 19149(PPP5C)(+)Loci: 3121 51796351-51805878 ~-10K 19157(CALM1)(+)Loci: 4403 51869413-51911506 ~-42K 19161(PRKD2)(-)Loci: 4404 52033262-52046043 ~-13K 19167(AP2S1)(-)Loci: 3115 50004177-50016517 ~-12K 19053(LU)(+)Link out to UCSC  
Loci: 2856 89491998-89580859 ~-89K 11593(TDP1)(+)Loci: 2857 89933128-89941704 ~-9K 11603(CALM1)(+)Loci: 4144 89331265-89490568 ~-159K 11590(-)Link out to UCSC