SynDB Home Page
SynDB Home Page

blue bulletSynDB protein details  

Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0CALCB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionCalcitonin gene-related peptide ii precursor (cgrp-ii) (beta-type cgrp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005625 soluble fraction (TAS)
0005184 neuropeptide hormone activity (TAS)
0006874 calcium ion homeostasis (TAS)
0007165 signal transduction (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/ [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner.roducing either the calcium regulatory hormone CT in the thyroid.r the neuropeptide calcitonin gene related peptide (CGRP) in the brain . In medullary carcinoma of the thyroid.oth peptides are produced .CGRP is a 37-residue peptide produced by alternative splicing of the CT gene. CGRP induces vasodilation in various vessels.ncluding those of the coronary.erebral and systemic vasculature. A neurotransmitter or neuro-modulator role is suggested by its abundance in the CNS . The structure of human CGRP has been determined by 1H NMR . The main conformational feature of the hormone is an N-terminal disulphide-bonded loop (residues 2-7).eading into a well-defined alpha-helix between residues 8 and 18; thereafter.he structure is predominantly disordered.lthough there are indications of a preference for a turn-type conformation between residues 19 and 21 .
  IPR002163:Calcitonin, beta type
InterPro domains unassigned to SynO:
Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood.y promoting the incorporation of these ions in the bones.lpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids.alled calcitonin gene-related peptide (CGRP).eta type. CGRP induces vasodilatation in a variety of vessels.ncluding the coronary.erebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) (also known as diabetes-associated peptide (DAP).r amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle.hile not affecting adipocyte glucose metabolism. Structurally.APP is closely related to CGRP.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.
Islet amyloid polypeptide (IAPP) (also known as diabetes-associated peptideor amylin) is a pancreatic islet hormone that is stored with insulin in betacell granules . IAPP has a propensity to form islet cell-disrupting amyloid deposits.nd opposes the action of insulin in peripheral tissues; the peptide may therefore have a significant role in the development of Type2 diabetes mellitus . It is thought that an intrinsic structural motif ofIAPP.hich only occurs in species that develop age-associated or Type 2 diabetes (e.g..umans and cats).s linked to its amyloidogenicity .IAPP is a short.7-residue peptide. The hormone selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle.ut does not affect adipocyte glucose metabolism. The sequences of amylinand the calcitonin gene-related peptides (CGRPs) show strong similarity:both peptides have a conserved N-terminal intramolecular disulphide bridge.nd both have a C-terminal glycine.hich suggests that the C-terminalresidue of amylin.ike that of CGRP.s amidated .Near- and far-UV CD spectra of human alpha CGRP.nalogues and fragments ofCGRP.nd amylin have been recorded in aqueous solution and in trifluoro-ethanol/water mixtures . The peptides were shown to contain significantamounts of alpha-helix in aqueous solution.his amount increasing upon addition of TFE. Amylin appears to contain less helix than CGRP .
  IPR000443:Islet amyloid protein
SequencesProtein: CALCB_HUMAN (127 aa)
mRNA: NM_000728
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords,domains)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:keywords,domains)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 22 residues, 15051721-15051785Exon2: 33 residues, 15052831-15052926Exon3: 48 residues, 15053182-15053320Exon4: 63 residues, 15055407-15055592Exon5: 185 residues, 15056204-15056753Exon6: 2 residues, -Jump to CALCB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2650 15051721-15056753 ~-5K 6380(CALCB)(+)Loci: 3938 14944791-14950408 ~-6K 6377(CALCA)(-)Link out to UCSC