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0CAD13_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDH13
DescriptionCadherin-13 precursor (truncated-cadherin) (t-cadherin) (t-cad) (heart-cadherin) (h-cadherin) (p105).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007155 cell adhesion (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
  IPR002126:Cadherin
IPR002126:Cadherin 
Evalue:-30.5376014709473 
Location:368-469IPR002126:Cadherin 
Evalue:-28.3098030090332 
Location:250-354IPR002126:Cadherin 
Evalue:-20.4814853668213 
Location:488-576IPR002126:CA 
Evalue:-17.2441251443275 
Location:160-243IPR002126:Cadherin 
Evalue:-13.6575775146484 
Location:588-680IPR002126:Cadherin 
Evalue:0 
Location:26-75
SequencesProtein: CAD13_HUMAN (713 aa)
mRNA: NM_001257
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentK06808
  Level 3 annotation:
    cadherin 13, H-cadherin
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 56 residues, 81218078-81218243Exon2: 39 residues, 81449467-81449579Exon3: 71 residues, 81623115-81623324Exon4: 41 residues, 81716490-81716607Exon5: 53 residues, 81808450-81808603Exon6: 50 residues, 81935967-81936112Exon7: 61 residues, 82077582-82077761Exon8: 49 residues, 82193559-82193700Exon9: 63 residues, 82261895-82262078Exon10: 86 residues, 82269313-82269567Exon11: 49 residues, 82339213-82339356Exon12: 80 residues, 82371073-82371307Exon13: 75 residues, 82374359-82374578Exon14: 525 residues, 82386128-82387698Exon15: 2 residues, -Jump to CAD13_HUMAN