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0CAD12_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionBrain-cadherin precursor (br-cadherin) (cadherin-12) (n-cadherin 2) (cadherin, neural type, 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0007156 homophilic cell adhesion (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation . Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn . The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin.ossibly through interaction with the cytoskeleton . This domain is found upstream of the cadherin domain .
  IPR000233:Cadherin cytoplasmic region
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
SequencesProtein: CAD12_HUMAN (794 aa)
mRNA: NM_004061
Local Annotation
Synapse Ontology
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentK06804
  Level 3 annotation:
    cadherin 12, type 2, N-cadherin 2
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 398 residues, 21786910-21788102Exon2: 86 residues, 21791456-21791708Exon3: 41 residues, 21796423-21796541Exon4: 42 residues, 21800843-21800965Exon5: 47 residues, 21819223-21819360Exon6: 86 residues, 21838032-21838286Exon7: 64 residues, 21852810-21852998Exon8: 58 residues, 21878026-21878194Exon9: 42 residues, 21890536-21890656Exon10: 100 residues, 22010956-22011251Exon11: 141 residues, 22114311-22114728Exon12: 50 residues, 22248363-22248509Exon13: 33 residues, 22441122-22441217Exon14: 33 residues, 22541135-22541230Exon15: 190 residues, 22888923-22889488Exon16: 2 residues, -Jump to CAD12_HUMAN