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0CAC1G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCACNA1G
DescriptionVoltage-dependent t-type calcium channel alpha-1g subunit (voltage- gated calcium channel alpha subunit cav3.1) (cav3.1c) (nbr13).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005891 voltage-gated calcium channel complex (TAS)
0008332 low voltage-gated calcium channel activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Cation channels are transport proteins responsible for the movement of cations through the membrane. These proteins contain 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times.hereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. Calcium channel proteins are involved in the control of neurotransmitterrelease from neurons .nd play an important role in the regulation ofa variety of cellular functions.ncluding membrane excitability.usclecontraction and synaptic transmission . The channel proteins arecomposed of 4 tightly-coupled subunits (alpha-1.lpha-2.eta and gamma).he alpha-1 subunit from each creating the pore for the import ofextracellular calcium ions. The alpha-1 subunit shares sequencecharacteristics with all voltage-dependent cation channels.nd exploitsthe same 6-helix bundle structural motif - in both sodium and calciumchannels.his motif is repeated 4 times within the sequence to give a24-helix bundle. There are several tissue-specific pharmacologically andelectrophysiologically distinct isoforms of calcium channels.oded forby separate genes in a multi-gene family. In skeletal muscle.achtightly-bound assembly of alpha.eta and gamma subunits associates with4 others to form a pentameric macromolecule .
  IPR002077:Ca2+ channel, alpha subunit
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by depolarizing stimuli.uch as action potentials.llows Ca2+ ions to enter neurons down a steep electrochemical gradient.roducing transient intracellular Ca2+ signals. Many of the processes that occur in neurons.ncluding transmitter release.ene transcription and metabolism are controlled by Ca2+ influx occurring simultaneously at different cellular locales. The activity of this pore is modulated by 4 tightly-coupled subunits: an intracellular beta subunit; a transmembrane gammasubunit; and a disulphide-linked complex of alpha-2 and delta subunits.hich are proteolytically cleaved from the same gene product. Voltage-gated calcium channels are classified as T.... and R.nd are distinguished by their sensitivity to pharmacological blocks.ingle-channel conductance kinetics.nd voltage-dependence. On the basis of their voltage activation properties.he voltage-gated calcium classes can be further divided into two broad groups: the low (T-type) and high (L... and R-type) threshold-activated channels . Generally.he channel proteins are composed of 4 tightly-coupled subunits (alpha-1.lpha-2.eta and gamma).he alpha-1 subunit from each creating the pore for the import of extracellular calcium ions. The alpha-1 subunit shares sequence characteristics with all voltage-dependent cation channels.nd exploits the same 6-helix bundle structural motif - in both sodium and calcium channels.his motif is repeated 4 times within the sequence to give a 24-helix bundle. Within each of these repeats. of the transmembrane (TM) segments (S1.2.3.5.6) are hydrophobic and one is positively charged (S4) - the latter is characterised by charged amino acids at very third position.nd probably represents the voltage-sensor. Several genes encoding alpha-1 subunits have been identified.ach forming a distinct electrophysiological channel. T-type calcium channels are composed of alpha-1G and alpha-1H subunits. They exhibit unique voltage- dependent kinetics.mall single channel conductance.apid inactivation.low deactivation and a relatively high permeability to calcium . They are primarily responsible for rebound burst firing in central neurons and are implicated in normal brain functions.uch as slow wave sleep.nd in diseased states.uch as epilepsy . They also play an important role in hormone secretion and smooth muscle excitability .
  IPR005445:T-type voltage-dependent calcium channel alpha 1 subunit
IPR005821:Ion_trans 
Evalue:-67.5086364746094 
Location:1312-1536IPR005821:Ion_trans 
Evalue:-64.853874206543 
Location:119-394IPR005821:Ion_trans 
Evalue:-58.7695503234863 
Location:1645-1850IPR005821:Ion_trans 
Evalue:-55.4948501586914 
Location:777-963IPR005445:TVDCCALPHA1 
Evalue:0 
Location:61-77IPR005445:TVDCCALPHA1 
Evalue:0 
Location:1548-1563IPR005445:TVDCCALPHA1 
Evalue:0 
Location:428-442IPR005445:TVDCCALPHA1 
Evalue:0 
Location:761-774
SequencesProtein: CAC1G_HUMAN (2377 aa)
mRNA: NM_018896 NM_198377
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords,domains)
?
sdb:0223 transmitter release  (Evidence:keywords,domains)
The action potential at the presynaptic region induces the opening of calcium channel, and the resulting calcium transient stimulates synaptic vesicle exocytosis.
sdb:0272 opening of Calcium channels  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04854
  Level 3 annotation:
    calcium channel, voltage-dependent, T type, alpha 1G subunit
  Level 2 annotation:
    Calcium signaling pathway
    Ion channels
    Type II diabetes mellitus
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 205 residues, 45993447-45994061Exon2: 39 residues, 46001229-46001341Exon3: 46 residues, 46001524-46001658Exon4: 34 residues, 46002065-46002163Exon5: 55 residues, 46004237-46004397Exon6: 102 residues, 46004913-46005214Exon7: 33 residues, 46005380-46005473Exon8: 263 residues, 46007902-46008686Exon9: 127 residues, 46010547-46010924Exon10: 52 residues, 46022830-46022982Exon11: 64 residues, 46023794-46023980Exon12: 40 residues, 46024098-46024213Exon13: 54 residues, 46024296-46024452Exon14: 25 residues, 46027352-46027421Exon15: 30 residues, 46028921-46029006Exon16: 66 residues, 46029089-46029283Exon17: 146 residues, 46031787-46032219Exon18: 35 residues, 46033085-46033186Exon19: 43 residues, 46033410-46033534Exon20: 25 residues, 46035179-46035248Exon21: 63 residues, 46035374-46035559Exon22: 44 residues, 46036514-46036641Exon23: 44 residues, 46038257-46038383Exon24: 32 residues, 46039259-46039349Exon25: 66 residues, 46040186-46040379Exon26: 20 residues, 46042241-46042295Exon27: 52 residues, 46047720-46047872Exon28: 38 residues, 46048634-46048744Exon29: 46 residues, 46049797-46049931Exon30: 25 residues, 46050218-46050289Exon31: 28 residues, 46050407-46050486Exon32: 42 residues, 46050581-46050703Exon33: 120 residues, 46051014-46051368Exon34: 50 residues, 46052042-46052186Exon35: 47 residues, 46054019-46054154Exon36: 58 residues, 46056266-46056435Exon37: 58 residues, 46056719-46056889Exon38: 353 residues, 46058376-46059430Exon39: 2 residues, -Jump to CAC1G_HUMANExon1: 205 residues, 45993447-45994061Exon2: 39 residues, 46001229-46001341Exon3: 46 residues, 46001524-46001658Exon4: 34 residues, 46002065-46002163Exon5: 55 residues, 46004237-46004397Exon6: 102 residues, 46004913-46005214Exon7: 33 residues, 46005380-46005473Exon8: 263 residues, 46007902-46008686Exon9: 127 residues, 46010547-46010924Exon10: 52 residues, 46022830-46022982Exon11: 64 residues, 46023794-46023980Exon12: 40 residues, 46024098-46024213Exon13: 54 residues, 46024296-46024452Exon14: 30 residues, 46028921-46029006Exon15: 66 residues, 46029089-46029283Exon16: 146 residues, 46031787-46032219Exon17: 35 residues, 46033085-46033186Exon18: 43 residues, 46033410-46033534Exon19: 25 residues, 46035179-46035248Exon20: 63 residues, 46035374-46035559Exon21: 44 residues, 46036514-46036641Exon22: 44 residues, 46038257-46038383Exon23: 32 residues, 46039259-46039349Exon24: 66 residues, 46040186-46040379Exon25: 20 residues, 46042241-46042295Exon26: 52 residues, 46047720-46047872Exon27: 38 residues, 46048634-46048744Exon28: 46 residues, 46049797-46049931Exon29: 25 residues, 46050218-46050289Exon30: 28 residues, 46050407-46050486Exon31: 42 residues, 46050581-46050703Exon32: 120 residues, 46051014-46051368Exon33: 50 residues, 46052042-46052186Exon34: 47 residues, 46054019-46054154Exon35: 58 residues, 46056266-46056435Exon36: 58 residues, 46056719-46056889Exon37: 353 residues, 46058376-46059430Exon38: 2 residues, -Jump to CAC1G_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4299 45545034-45562166 ~-17K 16176(-)Loci: 3018 45598389-45608288 ~-10K 16177(SGCA)(+)Loci: 4300 45800227-45805561 ~-5K 16185(MRPL27)(-)Loci: 3019 45965097-45975160 ~-10K 16195(EPN3)(+)Loci: 3020 45993447-46059430 ~-66K 16202(CACNA1G)(+)Loci: 3021 46067226-46124061 ~-57K 16218(ABCC3)(+)Loci: 3017 45527694-45543421 ~-16K 16175(PDK2)(+)Link out to UCSC