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0CABP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCABP1
DescriptionCalcium-binding protein 1 (cabp1) (calbrain).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (TAS)
0004857 enzyme inhibitor activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR002048:efhand 
Evalue:-9.45593166351318 
Location:162-190IPR002048:efhand 
Evalue:-7.85387182235718 
Location:85-113IPR002048:efhand 
Evalue:-5.09690999984741 
Location:199-226IPR002048:EF_HAND_2 
Evalue:0 
Location:135-152
SequencesProtein: CABP1_HUMAN (226 aa)
mRNA: NM_031205
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 119572753-119572868Exon2: 62 residues, 119578278-119578458Exon3: 12 residues, 119582063-119582094Exon4: 50 residues, 119582381-119582525Exon5: 38 residues, 119582916-119583026Exon6: 51 residues, 119583256-119583404Exon7: 151 residues, 119589060-119589508Exon8: 2 residues, -Jump to CABP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4079 119017288-119038982 ~-22K 9812(RAB35)(-)Loci: 4080 119132639-119187892 ~-55K 9820(PXN)(-)Loci: 2793 119360286-119362912 ~-3K 9830(COX6A1)(+)Loci: 4081 119383853-119391941 ~-8K 9835(SFRS9)(-)Loci: 2794 119392042-119420680 ~-29K 9836(DNCL1)(+)Loci: 2795 119572753-119589508 ~-17K 9842(CABP1)(+)Loci: 4078 118607977-118799478 ~-192K 9809(CIT)(-)Link out to UCSC