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0BZRP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBZRP
DescriptionPeripheral-type benzodiazepine receptor (pbr) (pkbs) (mitochondrial benzodiazepine receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005741 mitochondrial outer membrane (NAS)
0008503 benzodiazepine receptor activity (TAS)
0006626 protein-mitochondrial targeting (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light . It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase.hich is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates . The rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane.ut also to be able to functionally substitute for TspO in TspO- mutants.nd to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane . The biological significance of MBR remains unclear. It is thought to be involved in a variety of cellular functions.ncluding cholesterol transport in steroidogenic tissues.
  IPR004307:TspO/MBR-related protein
IPR004307:TspO_MBR 
Evalue:-89.3098068237305 
Location:5-156
SequencesProtein: BZRP_HUMAN (169 aa)
mRNA: NM_000714
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 41877478-41877554Exon2: 72 residues, 41885159-41885370Exon3: 48 residues, 41887001-41887140Exon4: 148 residues, 41888752-41889191Exon5: 2 residues, -Jump to BZRP_HUMAN  
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Loci Cluster (Details)Loci: 4575 41595721-41741095 ~-145K 24901(PACSIN2)(-)Loci: 4576 41765589-41815373 ~-50K 24903(TTLL1)(-)Loci: 3322 41877478-41889191 ~-12K 24908(BZRP)(+)Loci: 4574 41344764-41375349 ~-31K 24894(CYB5R3)(-)Link out to UCSC