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0BTBDC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBTBD12
DescriptionBtb/poz domain containing protein 12.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
IPR000210:BTB 
Evalue:-5.2518119729938 
Location:8-111
SequencesProtein: BTBDC_HUMAN (1151 aa)
mRNA: BC036335 NM_032444
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 505 residues, 3571183-3572695Exon2: 140 residues, 3573098-3573512Exon3: 36 residues, 3574770-3574873Exon4: 771 residues, 3579003-3581312Exon5: 57 residues, 3582700-3582867Exon6: 51 residues, 3584454-3584601Exon7: 6 residues, 3585606-3585620Exon8: 2 residues, -Jump to BTBDC_HUMANExon1: 505 residues, 3571183-3572695Exon2: 140 residues, 3573098-3573512Exon3: 36 residues, 3574770-3574873Exon4: 771 residues, 3579003-3581312Exon5: 57 residues, 3582700-3582867Exon6: 51 residues, 3584454-3584601Exon7: 31 residues, 3585606-3585695Exon8: 82 residues, 3586154-3586395Exon9: 107 residues, 3587380-3587697Exon10: 69 residues, 3587798-3588001Exon11: 73 residues, 3590980-3591193Exon12: 65 residues, 3592119-3592309Exon13: 77 residues, 3596475-3596700Exon14: 381 residues, 3598431-3599568Exon15: 10 residues, 3601561-3601586Exon16: 2 residues, -Jump to BTBDC_HUMAN  
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Loci Cluster (Details)Loci: 2919 3036682-3050723 ~-14K 13385(MMP25)(+)Loci: 4203 3232028-3246628 ~-15K 13403(MEFV)(-)Loci: 2920 3273487-3281456 ~-8K 13405(ZNF263)(+)Loci: 4204 3571183-3601586 ~-30K 13423(BTBD12)(-)Loci: 4205 3648039-3707514 ~-59K 13426(TRAP1)(-)Loci: 4206 3717719-3870723 ~-153K 13429(CREBBP)(-)Loci: 4202 2962794-2970475 ~-8K 13372(PKMYT1)(-)Link out to UCSC