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0BRD8_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBRD8
DescriptionBromodomain-containing protein 8 (p120) (skeletal muscle abundant protein) (thyroid hormone receptor coactivating protein 120kda) (trcp120).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0003706 ligand-regulated transcription factor activity (TAS)
0004887 thyroid hormone receptor activity (TAS)
0003713 transcription coactivator activity (TAS)
0003700 transcription factor activity (NAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Bromodomains are found in a variety of mammalian.nvertebrate and yeast DNA-binding proteins . Bromodomains can interact withacetylated lysine .In some proteins.he classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g..ammalian protein HRX.aenorhabditis elegans hypothetical protein ZK783.4.east protein YTA7). The bromodomain may occur as a single copy.r in duplicate. The precise function of the domain is unclear.ut it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation .
  IPR001487:Bromodomain
IPR001487:BROMO 
Evalue:-39.1079053973095 
Location:705-813IPR001487:BROMO 
Evalue:-31.6575773191778 
Location:1101-1209IPR001487:BROMODOMAIN_1 
Evalue:0 
Location:0-0
SequencesProtein: BRD8_HUMAN (1235 aa)
mRNA: NM_139199
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 8 residues, 137412871-137412892Exon2: 120 residues, 137520501-137520855Exon3: 37 residues, 137523656-137523761Exon4: 61 residues, 137524478-137524656Exon5: 25 residues, 137525383-137525452Exon6: 33 residues, 137525641-137525734Exon7: 73 residues, 137526717-137526932Exon8: 17 residues, 137527674-137527721Exon9: 33 residues, 137527907-137528001Exon10: 153 residues, 137528301-137528754Exon11: 95 residues, 137529415-137529696Exon12: 50 residues, 137531521-137531666Exon13: 75 residues, 137532057-137532276Exon14: 47 residues, 137532809-137532946Exon15: 23 residues, 137533932-137533997Exon16: 29 residues, 137534419-137534500Exon17: 43 residues, 137534625-137534748Exon18: 18 residues, 137534948-137534998Exon19: 25 residues, 137535652-137535722Exon20: 34 residues, 137541158-137541255Exon21: 2 residues, -Jump to Q58AB0_HUMANExon1: 133 residues, 137503358-137503754Exon2: 61 residues, 137504292-137504470Exon3: 25 residues, 137508764-137508833Exon4: 32 residues, 137509376-137509466Exon5: 54 residues, 137513227-137513385Exon6: 90 residues, 137514332-137514596Exon7: 95 residues, 137516069-137516348Exon8: 17 residues, 137523142-137523187Exon9: 37 residues, 137523656-137523761Exon10: 61 residues, 137524478-137524656Exon11: 25 residues, 137525383-137525452Exon12: 33 residues, 137525641-137525734Exon13: 73 residues, 137526717-137526932Exon14: 17 residues, 137527674-137527721Exon15: 33 residues, 137527907-137528001Exon16: 153 residues, 137528301-137528754Exon17: 95 residues, 137529415-137529696Exon18: 72 residues, 137530105-137530315Exon19: 50 residues, 137531521-137531666Exon20: 47 residues, 137532809-137532946Exon21: 23 residues, 137533932-137533997Exon22: 29 residues, 137534419-137534500Exon23: 43 residues, 137534625-137534748Exon24: 18 residues, 137534948-137534998Exon25: 25 residues, 137535652-137535722Exon26: 34 residues, 137541158-137541255Exon27: 26 residues, 137542183-137542257Exon28: 2 residues, -Jump to BRD8_HUMANExon1: 124 residues, 137520484-137520855Exon2: 17 residues, 137523142-137523187Exon3: 37 residues, 137523656-137523761Exon4: 61 residues, 137524478-137524656Exon5: 25 residues, 137525383-137525452Exon6: 33 residues, 137525641-137525734Exon7: 73 residues, 137526717-137526932Exon8: 17 residues, 137527674-137527721Exon9: 33 residues, 137527907-137528001Exon10: 153 residues, 137528301-137528754Exon11: 95 residues, 137529415-137529696Exon12: 72 residues, 137530105-137530315Exon13: 50 residues, 137531521-137531666Exon14: 75 residues, 137532057-137532276Exon15: 47 residues, 137532809-137532946Exon16: 23 residues, 137533932-137533997Exon17: 29 residues, 137534419-137534500Exon18: 43 residues, 137534625-137534748Exon19: 18 residues, 137534948-137534998Exon20: 25 residues, 137535652-137535722Exon21: 34 residues, 137541158-137541255Exon22: 7 residues, 137542183-137542199Exon23: 2 residues, -Jump to Q58AB0_HUMANExon1: 124 residues, 137520484-137520855Exon2: 17 residues, 137523142-137523187Exon3: 37 residues, 137523656-137523761Exon4: 61 residues, 137524478-137524656Exon5: 25 residues, 137525383-137525452Exon6: 33 residues, 137525641-137525734Exon7: 73 residues, 137526717-137526932Exon8: 17 residues, 137527674-137527721Exon9: 33 residues, 137527907-137528001Exon10: 153 residues, 137528301-137528754Exon11: 95 residues, 137529415-137529696Exon12: 72 residues, 137530105-137530315Exon13: 50 residues, 137531521-137531666Exon14: 75 residues, 137532057-137532276Exon15: 47 residues, 137532809-137532946Exon16: 23 residues, 137533932-137533997Exon17: 29 residues, 137534419-137534500Exon18: 43 residues, 137534625-137534748Exon19: 18 residues, 137534948-137534998Exon20: 25 residues, 137535652-137535722Exon21: 34 residues, 137541158-137541255Exon22: 26 residues, 137542183-137542257Exon23: 2 residues, -Jump to Q58AB0_HUMANExon1: 124 residues, 137520484-137520855Exon2: 37 residues, 137523656-137523761Exon3: 61 residues, 137524478-137524656Exon4: 25 residues, 137525383-137525452Exon5: 33 residues, 137525641-137525734Exon6: 73 residues, 137526717-137526932Exon7: 17 residues, 137527674-137527721Exon8: 33 residues, 137527907-137528001Exon9: 153 residues, 137528301-137528754Exon10: 95 residues, 137529415-137529696Exon11: 33 residues, 137530105-137530198Exon12: 50 residues, 137531521-137531666Exon13: 75 residues, 137532057-137532276Exon14: 47 residues, 137532809-137532946Exon15: 23 residues, 137533932-137533997Exon16: 27 residues, 137534424-137534500Exon17: 43 residues, 137534625-137534748Exon18: 18 residues, 137534948-137534998Exon19: 25 residues, 137535652-137535722Exon20: 34 residues, 137541158-137541255Exon21: 26 residues, 137542183-137542257Exon22: 2 residues, -Jump to Q58AB0_HUMANExon1: 115 residues, 137520513-137520855Exon2: 37 residues, 137523656-137523761Exon3: 61 residues, 137524478-137524656Exon4: 25 residues, 137525383-137525452Exon5: 33 residues, 137525641-137525734Exon6: 73 residues, 137526717-137526932Exon7: 17 residues, 137527674-137527721Exon8: 33 residues, 137527907-137528001Exon9: 153 residues, 137528301-137528754Exon10: 95 residues, 137529415-137529696Exon11: 50 residues, 137531521-137531666Exon12: 75 residues, 137532057-137532276Exon13: 44 residues, 137532809-137532937Exon14: 23 residues, 137533932-137533997Exon15: 29 residues, 137534419-137534500Exon16: 43 residues, 137534625-137534748Exon17: 18 residues, 137534948-137534998Exon18: 25 residues, 137535652-137535722Exon19: 34 residues, 137541158-137541255Exon20: 2 residues, -Jump to Q58AB0_HUMAN  
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Loci Cluster (Details)Loci: 4729 137412871-137542257 ~-129K 29467(-)Loci: 3480 137543247-137551259 ~-8K 29476(KIF20A)(+)Loci: 4730 137869686-137906817 ~-37K 29489(ETF1)(-)Loci: 4731 138236311-138238878 ~-3K 29494(LRRTM2)(-)Loci: 3479 137171360-137173313 ~-2K 29461(+)Link out to UCSC