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0BRCA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionBreast cancer type 2 susceptibility protein (fanconi anemia group d1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (TAS)
0005634 nucleus (IDA)
0030141 secretory granule (TAS)
0005515 protein binding (IPI)
0003697 single-stranded DNA binding (NAS)
0006338 chromatin remodeling (NAS)
0000724 double-strand break repair via homologous r... (NAS)
0006325 establishment and/or maintenance of chromat... (TAS)
0007093 mitotic checkpoint (NAS)
0000074 regulation of progression through cell cycle (TAS)
0007090 regulation of S phase of mitotic cell cycle (NAS)
0045449 regulation of transcription (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
The breast cancer type 2 susceptibility protein has a number of 39 amino acid repeats that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment . BRCA2 is a breast tumor suppressor with a potential function in the cellular response to DNA damage. At the cellular level.xpressionis regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA is found in S phase.uggesting BRCA2 may participate in regulating cell proliferation. There are eight repeats in BRCA2 designated as BRC1to BRC8. BRC1.RC2.RC3.RC4.RC7.nd BRC8 are highly conserved and bind to Rad51.hereas BRC5 and BRC6 are lesswell conserved and do not bind to Rad51 . It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.
  IPR002093:BRCA2 repeat
A five-stranded beta-barrel was first noted as a common structure among four proteins binding single-stranded nucleic acids (staphylococcal nuclease andaspartyl-tRNA synthetase) or oligosaccharides (B subunits of enterotoxin and verotoxin-1).nd has been termed the oligonucleotide/oligosaccharide binding motif.r OB fold. five-stranded beta-sheet coiled to form a closed beta-barrel capped by an alpha helix located between the third and fourth strands . Two ribosomal proteins.17 and members of this class.nd have different variations of the OB fold theme. Comparisons with other OB fold nucleic acid binding proteins suggest somewhat different mechanisms of nucleic acid recognition in each case .There are many nucleic acid-binding proteins that contain domains with this OB-fold structure.ncluding anticodon-binding tRNA synthetases.NA helicases RecG and RuvA.sDNA-binding proteins (BRCA2.DC13.elomere-end binding proteins).hage ssDNA-binding proteins (gp32.p2.5.pV).old shock proteins.NA ligases.NA-capping enzymes.NA replication initiators and RNA polymerase subunit RBP8 .Please be aware that some of the protein hits may be false positives.
  IPR008994:Nucleic acid-binding, OB-fold
This group represents a DNA recombination repair protein.RCA2 type. The BRCA2 tumour suppressor has been implicated in the maintenance of chromosomal stability through a function in DNA repair.robably in conjunction with the Rad51 recombinase. We propose that impaired homology-directed repair caused by BRCA2 deficiency leads to chromosomal instability and.ossibly.umorigenesis.hrough lack of repair or misrepair of DNA damage .
  IPR011370:DNA recombination repair protein, BRCA2
SequencesProtein: BRCA2_HUMAN (3418 aa)
mRNA: NM_000059
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
sdb:0265 cAMP mediated STP  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 63 residues, 31787616-31787804Exon2: 37 residues, 31788558-31788664Exon3: 85 residues, 31791213-31791462Exon4: 38 residues, 31797212-31797321Exon5: 18 residues, 31798237-31798287Exon6: 15 residues, 31798378-31798419Exon7: 40 residues, 31798635-31798750Exon8: 18 residues, 31801579-31801629Exon9: 39 residues, 31803055-31803167Exon10: 374 residues, 31804408-31805524Exon11: 1646 residues, 31808401-31813333Exon12: 34 residues, 31816694-31816790Exon13: 25 residues, 31818963-31819033Exon14: 144 residues, 31826997-31827425Exon15: 62 residues, 31828564-31828746Exon16: 64 residues, 31829878-31830066Exon17: 59 residues, 31834659-31834830Exon18: 120 residues, 31835315-31835670Exon19: 54 residues, 31842538-31842694Exon20: 50 residues, 31843092-31843237Exon21: 42 residues, 31848806-31848928Exon22: 68 residues, 31851453-31851652Exon23: 56 residues, 31851886-31852050Exon24: 48 residues, 31852143-31852282Exon25: 83 residues, 31866825-31867070Exon26: 51 residues, 31869034-31869181Exon27: 351 residues, 31870298-31871347Exon28: 22 residues, 31871745-31871805Exon29: 2 residues, -Jump to BRCA2_HUMAN  
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