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0BNIP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBNIP3
DescriptionBcl2/adenovirus e1b 19-kda protein-interacting protein 3.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (NAS)
0006916 anti-apoptosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several mammalian specific BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family. Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain.hich regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation.omodimerisation.s well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage.rior to the appearance of chromatin condensation or DNA fragmentation .
  IPR010548:BNIP3
IPR010548:BNIP3 
Evalue:-70.2518081665039 
Location:1-194
SequencesProtein: BNIP3_HUMAN (194 aa)
mRNA: NM_004052
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 291 residues, 133631193-133632063Exon2: 52 residues, 133634131-133634281Exon3: 37 residues, 133634357-133634464Exon4: 30 residues, 133636527-133636612Exon5: 52 residues, 133637286-133637437Exon6: 59 residues, 133645254-133645425Exon7: 2 residues, -Jump to BNIP3_HUMAN  
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