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0BKRB1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBDKRB1
DescriptionB1 bradykinin receptor (bk-1 receptor) (b1r).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004947 bradykinin receptor activity (TAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Bradykinins (BKs) are a family of short.tructurally similar peptides thatactivate sensory fibres.ontract venous smooth muscle.timulate releaseof cytokines.nduce connective tissue proliferation and mediate endothelium-dependent vasodilation. BK antagonists are of potential usein the treatment of inflammation.sthma.ild pain and endotoxic shock.BK receptors are widespread in peripheral tissues.nd at least 3 differentreceptor subtypes have been proposed. Of these.2 is the predominantsubtype.ediating slow contraction of various smooth muscles (includingveins.ntestine.terus.rachea and lung).nducing endothelium-dependentrelaxation of arteries and arterioles.nd stimulating natriuresis/diuresisin kidney. BK also induces hyperalgesia through activation of B2 receptorsin sensory nerve fibres and dorsal root ganglion neurons .
  IPR000496:Bradykinin receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Bradykinins (BKs) are a family of short.tructurally similar peptides thatactivate sensory fibres.ontract venous smooth muscle.timulate releaseof cytokines.nduce connective tissue proliferation and mediate endothelium-dependent vasodilation . BK antagonists are of potential usein the treatment of inflammation.sthma.ild pain and endotoxic shock.BK receptors are widespread in peripheral tissues.nd at least 3 differentreceptor subtypes have been proposed.esignated B1.2 and B3.B2 is the predominant bradykinin subtype. The B1 receptor has limiteddistribution in the periphery.ut has not been described in the CNS.It stimulates contraction of rabbit aorta and rat duodenum.nd mediatesrelaxation of rabbit mesenteric and coeliac arteries. In rabbitvascular smooth muscle.he expression of B1 receptors is increasedfollowing various pathological insults.n vitro or in vivo. In themajority of tissues.radykinin induces activation of phosphoinositidemetabolism via a pertussis-toxin-insensitive G-protein.robably of theGq/G11 class . It has also been reported to inhibit adenylyl cyclasethrough a persussis-toxin-insensitive G-protein.nd to raise levels ofcGMP and open ion channels. It also stimulates PLA2.ossibly by directactivation of a G-protein.
  IPR001186:B1 bradykinin receptor
IPR000276:7tm_1 
Evalue:-67.4559326171875 
Location:54-312IPR001186:BRADYKINNB1R 
Evalue:0 
Location:22-38IPR000496:BRADYKININR 
Evalue:0 
Location:313-325IPR000276:G_PROTEIN_RECEP_F1_1 
Evalue:0 
Location:0-0
SequencesProtein: BKRB1_HUMAN (353 aa)
mRNA: NM_000710
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03915
  Level 3 annotation:
    bradykinin receptor B1
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Regulation of actin cytoskeleton
    Complement and coagulation cascades
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 95792311-95792390Exon2: 41 residues, 95798741-95798860Exon3: 365 residues, 95799762-95800851Exon4: 2 residues, -Jump to BKRB1_HUMAN  
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