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0BID_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBID
DescriptionBh3 interacting domain death agonist (bid).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (TAS)
0005624 membrane fraction (TAS)
0005739 mitochondrion (TAS)
0005123 death receptor binding (TAS)
0005515 protein binding (IPI)
0008637 apoptotic mitochondrial changes (TAS)
0008625 induction of apoptosis via death domain rec... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
BID is a member of the Bcl-2 superfamily of proteins that are key regulators of programmed cell death.ence this family is related to the Apoptosis regulator Bcl-2 protein BH domain. BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event.xposing the BH3 domain and significantly changing the surface charge and hydrophobicity.hich causes a change of cellular localisation .
  IPR010479:BH3 interacting
IPR010479:BID 
Evalue:-152.086181640625 
Location:1-195
SequencesProtein: BID_HUMAN (195 aa)
mRNA: AY005151 NM_001196 NM_197966
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK04726
  Level 3 annotation:
    BH3 interacting domain death agonist
  Level 2 annotation:
    Apoptosis
    Natural killer cell mediated cytotoxicity
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 485 residues, 16596905-16598357Exon2: 73 residues, 16600782-16600995Exon3: 48 residues, 16602114-16602254Exon4: 72 residues, 16606568-16606779Exon5: 25 residues, 16612870-16612940Exon6: 39 residues, 16637146-16637258Exon7: 2 residues, -Jump to BID_HUMANExon1: 485 residues, 16596905-16598357Exon2: 73 residues, 16600782-16600995Exon3: 48 residues, 16602114-16602254Exon4: 72 residues, 16606568-16606779Exon5: 25 residues, 16612870-16612940Exon6: 136 residues, 16636375-16636779Exon7: 2 residues, -Jump to BID_HUMANExon1: 32 residues, 16598264-16598357Exon2: 73 residues, 16600782-16600995Exon3: 48 residues, 16602114-16602254Exon4: 33 residues, 16602847-16602942Exon5: 72 residues, 16606568-16606779Exon6: 25 residues, 16612870-16612940Exon7: 12 residues, 16637146-16637178Exon8: 2 residues, -Jump to BID_HUMAN  
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Loci Cluster (Details)Loci: 4555 16596905-16637258 ~-40K 24143(BID)(-)Loci: 3295 16973558-16994498 ~-21K 24153(TUBA8)(+)Loci: 4556 17280294-17304066 ~-24K 24158(PRODH)(-)Loci: 4557 17543094-17546285 ~-3K 24164(SLC25A1)(-)Loci: 4558 17698223-17799219 ~-101K 24167(HIRA)(-)Loci: 3296 18081986-18090842 ~-9K 24176(SEPT5)(+)Loci: 4559 18243045-18309515 ~-66K 24188(TXNRD2)(-)Loci: 3297 18309308-18336528 ~-27K 24191(COMT)(+)Loci: 3294 16423182-16453647 ~-30K 24138(SLC25A18)(+)Link out to UCSC