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0BDNF_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBDNF
DescriptionBrain-derived neurotrophic factor precursor (bdnf).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008083 growth factor activity (TAS)
0007399 neurogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
During the development of the vertebrate nervous system.any neuronsbecome redundant (because they have died.ailed to connect to targetcells.tc.) and are eliminated. At the same time.eveloping neurons sendout axon outgrowths that contact their target cells . Such cells controltheir degree of innervation (the number of axon connections) by thesecretion of various specific neurotrophic factors that are essential forneuron survival. One of these is nerve growth factor (NGF or beta-NGF). vertebrate protein that stimulatesdivision and differentiation of sympathetic and embryonic sensory neurons . NGF is mostly found outside the centralnervous system (CNS).ut slight traces have been detected in adult CNStissues.lthough a physiological role for this is unknown ; it has alsobeen found in several snake venoms .NGF is a protein of about 120 residues that is cleaved from a largerprecursor molecule. It contains six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of NGF is shownbelow:
  IPR002072:Nerve growth factor
IPR002072:NGF 
Evalue:-89.0861892700195 
Location:130-247
SequencesProtein: BDNF_HUMAN (247 aa)
mRNA: NM_170731 NM_170734 NM_170735
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:keywords)
KO assignmentK04355
  Level 3 annotation:
    brain-derived neurotrophic factor
  Level 2 annotation:
    MAPK signaling pathway
    Cytokines
    Huntington's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1411 residues, 27633017-27637249Exon2: 2 residues, -Jump to BDNF_HUMANExon1: 1231 residues, 27633017-27636708Exon2: 86 residues, 27677504-27677756Exon3: 2 residues, -Jump to BDNF_HUMANExon1: 1231 residues, 27633017-27636708Exon2: 114 residues, 27699534-27699872Exon3: 2 residues, -Jump to BDNF_HUMAN  
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Loci Cluster (Details)Loci: 3942 27633017-27699872 ~-67K 6483(BDNF)(-)Loci: 3941 27472699-27484879 ~-12K 6482(LIN7C)(-)Link out to UCSC