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0BCN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBECN1
DescriptionBeclin-1 (coiled-coil myosin-like bcl2-interacting protein) (protein gt197).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006916 anti-apoptosis (TAS)
0006968 cellular defense response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
In yeast.5 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells . Apg6/Vps30p has two distinct functions in the autophagic process.ither associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway .
  IPR007243:Autophagy protein Apg6
ERM proteins.ighly related members of the larger protein 4.1 superfamily.an exist in an active or inactive conformation. The sole Drosophila ERM protein.oesin.unctions to promote cortical actin assembly and apical-basal polarity. As a result.ells lacking Moesin lose epithelial characteristics and adopt invasive migratory behaviour. Moesin appears to facilitate epithelial morphology not by providing an essential structural function.ut rather by antagonizing activity of the small GTPase Rho. Thus.oesin functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin organization and polarity .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008954:Moesin
IPR007243:APG6 
Evalue:-235 
Location:115-450
SequencesProtein: BCN1_HUMAN (450 aa)
mRNA: NM_003766
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 266 residues, 38215677-38216472Exon2: 49 residues, 38217198-38217341Exon3: 22 residues, 38219491-38219552Exon4: 52 residues, 38220067-38220217Exon5: 51 residues, 38221451-38221598Exon6: 67 residues, 38223764-38223959Exon7: 47 residues, 38224087-38224224Exon8: 32 residues, 38224330-38224421Exon9: 22 residues, 38225091-38225153Exon10: 24 residues, 38226317-38226385Exon11: 46 residues, 38229291-38229423Exon12: 45 residues, 38229676-38229807Exon13: 2 residues, -Jump to BCN1_HUMAN  
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Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC