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0BCLX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBCL2L1
DescriptionApoptosis regulator bcl-x (bcl-2-like 1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005741 mitochondrial outer membrane (NAS)
0005739 mitochondrion (TAS)
0005515 protein binding (IPI)
0006916 anti-apoptosis (TAS)
0006915 apoptosis (TAS)
0008637 apoptotic mitochondrial changes (TAS)
0008634 negative regulation of survival gene produc... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins.It is controlled by regulators.hich have either an inhibitory effect on programmed cell death(anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic) . Many viruses have found a way of countering defensive apoptosis by encoding their ownanti-apoptosis genes preventing their target-cells from dying too soon. All proteins belonging tothe Bcl-2 family contain either a BH1.H2.H3.r BH4 domain. All anti-apoptoticproteins contain BH1 and BH2 domains.ome of them contain an additional N-terminal BH4 domain(Bcl-2.cl-x(L).cl-w).hich is never seen in pro-apoptotic proteins.xcept for Bcl-x(S). On theother hand.ll pro-apoptotic proteins contain a BH3 domain (except for Bad) necessary fordimerization with other proteins of Bcl-2 family and crucial for their killing activity.ome of themalso contain BH1 and BH2 domains (Bax.ak). The BH3 domain is also present in some anti-apoptoticprotein.uch as Bcl-2 or Bcl-x(L). Proteins that are known to contain these domains include vertebrateBcl-2 (alpha and beta isoforms) and Bcl-x (isoforms (Bcl-x(L) and Bcl-x(S)); mammalian proteins Bax andBak; mouse protein Bid; Xenopus laevis proteins Xr1 and Xr11; human induced myeloid leukemia celldifferentiation protein MCL1 and Caenorhabditis elegans protein ced-9.
  IPR000712:Apoptosis regulator Bcl-2, BH
Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins.It is controlled by regulators.hich have either an inhibitory effect on programmed cell death(anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic) . Many viruses have found a way of countering defensive apoptosis by encoding their ownanti-apoptosis genes preventing their target-cells from dying too soon. PAll proteins belonging tothe Bcl-2 family contain either a BH1.H2.H3.r BH4 domain. All anti-apoptoticproteins contain BH1 and BH2 domains.ome of them contain an additional N-terminal BH4 domain(Bcl-2.cl-x(L).cl-w).hich is never seen in pro-apoptotic proteins.xcept for Bcl-x(S). On theother hand.ll pro-apoptotic proteins contain a BH3 domain (except for Bad) necessary fordimerization with other proteins of Bcl-2 family and crucial for their killing activity.ome of themalso contain BH1 and BH2 domains (Bax.ak). The BH3 domain is also present in some anti-apoptoticprotein.uch as Bcl-2 or Bcl-x(L). Proteins that are known to contain these domains include vertebrateBcl-2 (alpha and beta isoforms) and Bcl-x (isoforms (Bcl-x(L) and Bcl-x(S)); mammalian proteins Bax andBak; mouse protein Bid; Xenopus laevis proteins Xr1 and Xr11; human induced myeloid leukemia celldifferentiation protein MCL1 and Caenorhabditis elegans protein ced-9.
  IPR003093:Apoptosis regulator Bcl-2 protein, BH4
Bcl-X is a dominant regulator of programmed cell death in mammalian cells. The long form (Bcl-X(L)) displays cell death repressor activity.ut the short isoform (Bcl-X(S)) and the b-isoform (Bcl-Xb) promote cell death. Bcl-X(L).cl-X(S) and Bcl-Xb are three isoforms derived by alternative RNA splicing. Bcl-X(S) forms heterodimers with Bcl-2. Homologues of Bcl-X include the rat Bax and mouse Bak proteins which also influence apoptosis.
  IPR004725:Apoptosis regulator Bcl-X protein
This group represents a Bcl2 related apoptosis regulator. Please see the following relevant reference: .
  IPR012238:Bcl2 related apoptosis regulator
Apoptosis.r programmed cell death (PCD).s a common and evolutionarily conserved property of all metazoans . In many biological processes.poptosis is required to eliminate supernumerary or dangerous (e.g..re- cancerous) cells and to promote normal development. Thus.ysregulation of apoptosis can contribute to the development of many major diseases.ncluding cancer.utoimmunity and neurodegenerative disorders. In most cases.roteins of the caspase family execute the genetic programme that leads to cell death. Bcl-2 proteins are central regulators of caspase activation.nd play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum membranes . At least 20 Bcl-2 proteins have been reported in mammals.nd several others have been identified in viruses. Bcl-2 family proteins fall roughly into three subtypes.hich either promote cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All members contain at least one of four conserved motifs.ermed Bcl-2 Homology (BH) domains. Bcl-2 subfamily proteins.hich contain at least BH1 and BH2.romote cell survival by inhibiting the adapters needed for the activation of caspases. Pro-apoptotic members potentially exert their effects by displacing the adapters from the pro-survival proteins; these proteins belong either to the Bax subfamily.hich contain BH1-BH3.r to the BH3 subfamily.hich mostly only feature BH3 . Thus.he balance between antagonistic family members is believed to play a role in determining cell fate. Members of the wider Bcl-2 family.hich also includes Bcl-x.cl-w and Mcl-1.re described by their similarity to Bcl-2 protein. member of the pro-survival Bcl-2 subfamily . In healthy cells.cl-xl resides in the cytoplasm and becomes membrane-associated in response to cytotoxic insults. Its 3D structure comprises a bundle of five amphipathic alpha- helices surrounding two central hydrophobic helical regions. A hydro- phobic groove.ormed by residues from BH1-BH3.s capable of binding the BH3 alpha-helix from a pro-apoptotic BH3-only family member .
  IPR013279:Apoptosis regulator, Bcl-X
IPR000712:Bcl-2 
Evalue:-58.3665313720703 
Location:90-188IPR003093:BH4 
Evalue:-13.6020603179932 
Location:1-27
SequencesProtein: BCLX_HUMAN (233 aa)
mRNA: NM_138578
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK04570
  Level 3 annotation:
    BCL2-like 1 (apoptosis regulator Bcl-X)
  Level 2 annotation:
    Jak-STAT signaling pathway
    Apoptosis
    Amyotrophic lateral sclerosis (ALS)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 543 residues, 29715923-29717550Exon2: 233 residues, 29773118-29773812Exon3: 80 residues, 29774081-29774317Exon4: 2 residues, -Jump to BCLX_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3245 29689351-29696461 ~-7K 22847(COX4I2)(+)Loci: 4514 29715923-29774317 ~-58K 22848(BCL2L1)(-)Loci: 3243 29492071-29501720 ~-10K 22838(DEFB123)(+)Link out to UCSC