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0BCKD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
Description kinase, mitochondrial precursor (ec (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in several ATP-binding proteins for example: histidine kinase.NA gyrase B.opoisomerases .eat shock protein HSP90 .hytochrome-like ATPases and DNA mismatch repair proteins.
  IPR003594:ATP-binding region, ATPase-like
This domain is present in many sensor proteins that respond to extra-cytoplasmic stimuli in bacteria.ut is also found in many proteins of metazoan origin. Sensors are usually linked to a 2-component regulatory system consisting of the sensor and a cytoplasmic regulator protein . The cytoplasmic C-terminal portions of the sensor proteins show marked sequence similarity and are responsible for kinase activity . Some sensor proteins are cytoplasmic and may respond to several external stimuli. Sensors also show similarity to some regulatory proteins . The structure of CheA. signal-transducing histidine kinase is known . The catalytic domain consists of several alpha-helices packed over one face of a large anti-parallel beta sheet forming a loop which closes over the bound ATP. Hydrolysis of ATP is coupled to Mg 2+ release and conformational changes in the ATP-binding cavity.
  IPR004358:Histidine kinase related protein, C-terminal
SequencesProtein: BCKD_HUMAN (412 aa)
mRNA: NM_005881
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00905
  Level 3 annotation:
    [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 18 residues, 31027248-31027301Exon2: 126 residues, 31027868-31028240Exon3: 25 residues, 31028332-31028401Exon4: 39 residues, 31028494-31028605Exon5: 18 residues, 31028898-31028946Exon6: 42 residues, 31029026-31029146Exon7: 35 residues, 31029222-31029321Exon8: 26 residues, 31029509-31029583Exon9: 45 residues, 31029912-31030041Exon10: 32 residues, 31030121-31030211Exon11: 55 residues, 31030690-31030849Exon12: 161 residues, 31030942-31031420Exon13: 2 residues, -Jump to BCKD_HUMAN  
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Loci Cluster (Details)Loci: 2937 30952403-30958985 ~-7K 13959(STX4A)(+)Loci: 2938 31027248-31031420 ~-4K 13969(BCKDK)(+)Loci: 4219 30910868-30929276 ~-18K 13957(STX1B2)(-)Link out to UCSC