SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0BCAT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBCAT2
DescriptionBranched-chain-amino-acid aminotransferase, mitochondrial precursor (ec 2.6.1.42) (bcat(m)) (placental protein 18) (pp18).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004084 branched-chain-amino-acid transaminase acti... (TAS)
0009082 branched chain family amino acid biosynthesis (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/101678752.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into subfamilies.One of these.alled class-IV.urrently consists of proteins of about 270 to 415 amino-acid residues that share a few regions of sequence similarity. Surprisingly.he best conserved region does not include the lysine residue to which the pyridoxal-phosphate group is known to be attached.n ilvE.ut is located some 40 residues at the C terminus side of the pyridoxal-phosphate-lysine. The D-amino acid transferases (D-AAT).hich are among the members of this entry.re required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine.hich are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates.-AATs and L-ATTs have strong similarity .
  IPR001544:Aminotransferase, class IV
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into subfamilies.One of these.alled class-IV.urrently consists of proteins of about 270 to 415 amino-acid residues that share a few regions of sequence similarity. Surprisingly.he best conserved region does not include the lysine residue to which the pyridoxal-phosphate group is known to be attached.n ilvE.ut is located some 40 residues at the C-terminus side of the PlP-lysine. Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE) (). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family.
  IPR005786:Branched-chain amino acid aminotransferase II
IPR001544:Aminotran_4 
Evalue:-162.53759765625 
Location:77-377
SequencesProtein: BCAT2_HUMAN (392 aa)
mRNA: NM_001190
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00826
  Level 3 annotation:
    branched-chain amino acid aminotransferase
  Level 2 annotation:
    Valine
     leucine and isoleucine degradation
    Valine
     leucine and isoleucine biosynthesis
    Pantothenate and CoA biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 135 residues, 53990131-53990533Exon2: 27 residues, 53991496-53991571Exon3: 49 residues, 53991646-53991787Exon4: 30 residues, 53992005-53992091Exon5: 49 residues, 53992259-53992402Exon6: 56 residues, 53994743-53994907Exon7: 42 residues, 53995049-53995169Exon8: 39 residues, 53995255-53995366Exon9: 69 residues, 54001585-54001786Exon10: 27 residues, 54002068-54002143Exon11: 22 residues, 54006052-54006113Exon12: 2 residues, -Jump to BCAT2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3124 53589943-53639205 ~-49K 19224(GRIN2D)(+)Loci: 3125 53656317-53661179 ~-5K 19226(KCNJ14)(+)Loci: 3126 53747240-53794495 ~-47K 19229(SULT2B1)(+)Loci: 4406 53833083-53841263 ~-8K 19240(CA11)(-)Loci: 4407 53990131-54006113 ~-16K 19255(BCAT2)(-)Loci: 4408 54262487-54268010 ~-6K 19284(-)Loci: 3127 54309429-54313528 ~-4K 19290(LIN7B)(+)Loci: 3128 54314474-54346090 ~-32K 19292(PPFIA3)(+)Loci: 4409 54484705-54520286 ~-36K 19297(SLC6A16)(-)Loci: 3129 54669297-54681299 ~-12K 19311(FLT3LG)(+)Loci: 4410 54854641-54860926 ~-6K 19323(IRF3)(-)Loci: 3130 54886218-54908800 ~-23K 19334(CPT1C)(+)Loci: 3131 54961991-55002179 ~-40K 19337(AP2A1)(+)Loci: 3132 55124271-55129003 ~-5K 19355(ATF5)(+)Loci: 4411 55510576-55524446 ~-14K 19365(KCNC3)(-)Loci: 4412 55817047-55833114 ~-16K 19382(SYT3)(-)Loci: 4413 55856895-55912007 ~-55K 19383(SHANK1)(-)Loci: 3123 53559468-53571439 ~-12K 19220(SYNGR4)(+)Link out to UCSC