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0BAIP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBAIAP3
DescriptionBai1-associated protein 3 (bap3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008022 protein C-terminus binding (TAS)
0007269 neurotransmitter secretion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is often found in tandem repeats and co-occur with C2 domains .rotein kinase C.horbol ester/diacylglycerol binding regions and PH domains .
  IPR010439:Protein of unknown function DUF1041
The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes.ncluding phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported.he domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif.esignated a C2 key . Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.
  IPR000008:C2 calcium-dependent membrane targeting
The Ca2+-dependent.ipid-binding domain (CaLB) has been identified in a number of proteins.or example the amino-terminal.38 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008973:C2 calcium/lipid-binding region, CaLB
IPR010439:DUF1041 
Evalue:-24.4317989349365 
Location:561-642IPR000008:C2 
Evalue:-24.3665313720703 
Location:1027-1119IPR000008:C2 
Evalue:-19.6989707946777 
Location:197-306
SequencesProtein: BAIP3_HUMAN (1187 aa)
mRNA: NM_003933
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 32 residues, 1324663-1324758Exon2: 49 residues, 1328541-1328682Exon3: 31 residues, 1328903-1328991Exon4: 29 residues, 1329165-1329246Exon5: 38 residues, 1329497-1329605Exon6: 22 residues, 1330923-1330983Exon7: 24 residues, 1331130-1331197Exon8: 67 residues, 1331295-1331491Exon9: 17 residues, 1331823-1331868Exon10: 28 residues, 1331987-1332065Exon11: 36 residues, 1332182-1332285Exon12: 38 residues, 1332528-1332636Exon13: 34 residues, 1332720-1332816Exon14: 36 residues, 1332914-1333018Exon15: 42 residues, 1333394-1333515Exon16: 43 residues, 1334023-1334148Exon17: 32 residues, 1334228-1334319Exon18: 21 residues, 1334470-1334527Exon19: 34 residues, 1334602-1334700Exon20: 19 residues, 1334799-1334851Exon21: 45 residues, 1334970-1335101Exon22: 43 residues, 1335250-1335374Exon23: 50 residues, 1335748-1335892Exon24: 33 residues, 1335987-1336080Exon25: 66 residues, 1336171-1336363Exon26: 25 residues, 1336443-1336512Exon27: 28 residues, 1336606-1336686Exon28: 38 residues, 1336848-1336957Exon29: 26 residues, 1337299-1337371Exon30: 29 residues, 1337546-1337627Exon31: 42 residues, 1337702-1337823Exon32: 43 residues, 1337895-1338019Exon33: 70 residues, 1338097-1338303Exon34: 356 residues, 1338380-1339443Exon35: 2 residues, -Jump to BAIP3_HUMAN  
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Loci Cluster (Details)Loci: 2909 387192-390754 ~-4K 13162(NME4)(+)Loci: 2910 415668-512481 ~-97K 13166(RAB11FIP3)(+)Loci: 2911 580179-619272 ~-39K 13173(RAB40C)(+)Loci: 4199 774975-778384 ~-3K 13216(-)Loci: 2912 1143241-1211772 ~-69K 13223(CACNA1H)(+)Loci: 2913 1324663-1339443 ~-15K 13234(BAIAP3)(+)Loci: 4200 1435345-1465013 ~-30K 13244(CLCN7)(-)Loci: 2914 1696221-1760318 ~-64K 13253(MAPK8IP3)(+)Loci: 2915 1979968-1984276 ~-4K 13288(SYNGR3)(+)Loci: 2916 2016896-2028484 ~-12K 13290(SLC9A3R2)(+)Loci: 2917 2038599-2078713 ~-40K 13294(TSC2)(+)Loci: 2918 2138651-2144141 ~-5K 13300(RAB26)(+)Loci: 4201 2167184-2186466 ~-19K 13303(CASKIN1)(-)Loci: 4198 357394-360541 ~-3K 13159(MRPL28)(-)Link out to UCSC