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0BAIP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionBrain-specific angiogenesis inhibitor 1-associated protein 2 (bai1- associated protein 2) (bai-associated protein 2) (bap2 protein) (insulin receptor substrate p53) (irsp53) (insulin receptor substrate protein of 53 kda) (insulin receptor substrate p53/p58) (irsp53/58) (irs-58) (fas-ligand associated factor 3) (flaf3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent .
  IPR013606:IRSp53/MIM homology domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. These were first described in the Src cytoplasmic tyrosine kinase . The structure is a partly opened beta barrel.
  IPR011511:Variant SH3
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
SequencesProtein: BAIP2_HUMAN (552 aa)
mRNA: NM_017451
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords)
KO assignmentK05627
  Level 3 annotation:
    BAI1-associated protein 2
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Adherens junction
    Dentatorubropallidoluysian atrophy (DRPLA)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 50 residues, 76623556-76623703Exon2: 27 residues, 76642062-76642138Exon3: 31 residues, 76646275-76646362Exon4: 22 residues, 76673226-76673288Exon5: 26 residues, 76674048-76674120Exon6: 48 residues, 76674837-76674975Exon7: 53 residues, 76688322-76688475Exon8: 76 residues, 76691896-76692118Exon9: 69 residues, 76692301-76692503Exon10: 69 residues, 76692908-76693110Exon11: 25 residues, 76694472-76694541Exon12: 56 residues, 76695139-76695302Exon13: 13 residues, 76696869-76696904Exon14: 18 residues, 76704164-76704212Exon15: 403 residues, 76704624-76705827Exon16: 2 residues, -Jump to BAIP2_HUMAN  
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Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC