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0BAI2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameBAI2
DescriptionBrain-specific angiogenesis inhibitor 2 precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0016527 brain-specific angiogenesis inhibitor activity (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.
  IPR000832:GPCR, family 2, secretin-like
This domain has been termed the GPS domain (for GPCR proteolytic site).ecause it contains a cleavage site in latrophilin . However this region in latrophilin is found in many otherwise unrelated cell surface receptors . There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
  IPR000203:GPS
This domain is found in the extracellular part of some hormone receptors including the calcitonin receptor; corticotropin releasing factor receptor 1; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor.
  IPR001879:Hormone receptor, extracellular
This repeat was first described in 1986 by Lawler and Hynes . It was found in the thrombospondin protein where it is repeated 3 times. Now a number of proteins involved in the complement pathway (properdin.6.7.8A.8B.9) as well as extracellular matrix protein like mindin.-spondin .CO-spondin and even the circumsporozoite surface protein 2 and TRAP proteins of Plasmodium .ontain one or more instance of this repeat.It has been involved in cell-cell interraction.nhibition of angiogenesis andapoptosis . The intron-exon organisation of the properdin gene confirms the hypothesis that the repeat might have evolved by a process involving exon shuffling .A study of properdin structure provides some information about the structure ofthe thrombospondin type I repeat .
  IPR000884:Thrombospondin, type I
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.Three human secretin-like GPCRs that are expressed specifically in thebrain.nd appear to have a role in the inhibition of angiogenesis.avebeen identified and named BAI (brain-specific angiogenesis inhibitor) 1-3. In addition to the characteristic 7 TM domains.he BAIs also have alarge extracellular domain containing a number of thrombospondin type 1 repeats - these have been shown to inhibit in vivo angiogenesis induced bybFGF in rat cornea. BAI1 has been found to be transcriptionally regulated by p53 and is absent in many glioblastoma cell lines.uggestingthat it may play an important role in suppression of the disease.
  IPR008077:Brain-specific angiogenesis inhibitor
The TSP1 (thrombospondin 1) repeat was first identified in thethrombospondin protein.here it is repeated 3 times . The domain is ~60 amino acid residues in length and is characterised by a highly conserved W-S-X-W motif and six cysteine residues. TSP1 repeats have been identified in a number of proteins including: the complement pathwayproteins properdin.6.7.8A.8B and C9; extracellular matrix proteins.ncluding mindin.DAMTS and F-spondin; Plasmodium TRAP proteins; and G protein-coupled receptors.uch as the brain-specific angiogenesis inhibitors. The domains have a number of functions.ncluding effects on cell attachment.otility.roliferation.he activities of extracellularproteases.nd inhibition of angiogenesis.ontributing to vascular homeostasis. A study of the structure of properdin indicates that the TSP1 repeat contains two amphipathic turn regions and a hydrophilic beta-strand .
  IPR008085:Thrombospondin, subtype 1
IPR000832:7tm_2 
Evalue:-90.7695541381836 
Location:917-1197IPR000203:GPS 
Evalue:-23.2076091766357 
Location:858-911IPR001879:HormR 
Evalue:-17.267606240177 
Location:518-584IPR000884:TSP1 
Evalue:-12.7447274948967 
Location:355-405IPR000884:TSP_1 
Evalue:-11.408935546875 
Location:301-349IPR000884:TSP1 
Evalue:-9.48148606012211 
Location:466-516IPR000884:TSP1 
Evalue:-8.09691001300806 
Location:410-460IPR008077:BAIPRECURSOR 
Evalue:0 
Location:725-746IPR008077:BAIPRECURSOR 
Evalue:0 
Location:622-641IPR008077:BAIPRECURSOR 
Evalue:0 
Location:53-70IPR008077:BAIPRECURSOR 
Evalue:0 
Location:1446-1460IPR008077:BAIPRECURSOR 
Evalue:0 
Location:1462-1476IPR008077:BAIPRECURSOR 
Evalue:0 
Location:1226-1239IPR008077:BAIPRECURSOR 
Evalue:0 
Location:664-673IPR000832:G_PROTEIN_RECEP_F2_2 
Evalue:0 
Location:0-0
SequencesProtein: BAI2_HUMAN (1572 aa)
mRNA: NM_001703
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04597
  Level 3 annotation:
    brain-specific angiogenesis inhibitor 2
  Level 2 annotation:
    G-protein coupled receptors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 163 residues, 31965305-31965793Exon2: 21 residues, 31966212-31966269Exon3: 34 residues, 31966369-31966465Exon4: 14 residues, 31966785-31966821Exon5: 208 residues, 31968987-31969607Exon6: 15 residues, 31970302-31970342Exon7: 34 residues, 31970704-31970800Exon8: 59 residues, 31971159-31971331Exon9: 35 residues, 31973370-31973469Exon10: 30 residues, 31973767-31973853Exon11: 24 residues, 31974014-31974081Exon12: 25 residues, 31974508-31974578Exon13: 52 residues, 31974760-31974911Exon14: 36 residues, 31975616-31975719Exon15: 36 residues, 31975839-31975943Exon16: 44 residues, 31976387-31976514Exon17: 16 residues, 31976774-31976818Exon18: 37 residues, 31977019-31977125Exon19: 111 residues, 31977495-31977823Exon20: 38 residues, 31978113-31978222Exon21: 25 residues, 31978297-31978366Exon22: 67 residues, 31978534-31978729Exon23: 37 residues, 31979560-31979667Exon24: 36 residues, 31979811-31979913Exon25: 58 residues, 31979987-31980155Exon26: 57 residues, 31980240-31980405Exon27: 57 residues, 31981025-31981190Exon28: 57 residues, 31982380-31982545Exon29: 30 residues, 31982835-31982919Exon30: 274 residues, 31994186-31995003Exon31: 29 residues, 31995388-31995469Exon32: 45 residues, 31995569-31995699Exon33: 52 residues, 32002071-32002223Exon34: 2 residues, -Jump to BAI2_HUMAN  
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Loci Cluster (Details)Loci: 3788 31965305-32002223 ~-37K 944(BAI2)(-)Loci: 2501 32417931-32436472 ~-19K 964(TXLNA)(+)Loci: 2502 32489505-32524350 ~-35K 978(LCK)(+)Loci: 3789 32572027-32574410 ~-2K 982(MARCKSL1)(-)Loci: 2500 31857227-31865301 ~-8K 939(HCRTR1)(+)Link out to UCSC